Stereochemical Studies in Allylmetal-Aldehyde, -Acetal and Aldol Reactions

烯丙基金属醛、乙缩醛和羟醛反应的立体化学研究

• 批准号: 8818147
• 负责人: Scott Denmark
• 金额: $ 17.98万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-15 至 1992-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8818147&HistoricalAwards=false
• 关键词: Stereochemical; Studies; Allylmetal; Aldehyde; Acetal

The Organic Synthesis Program supports the work of Scott Denmark, of the University of Illinois. Prof. Denmark's work involves examining how a reaction central to organic synthesis and biochemistry, the aldol condensation, can result in compounds with unique spatial orientations of atoms. The orientation in space of atoms can have profound effects on both chemical and biological behavior of molecules, and it is one of the challenges of modern organic chemists to understand how reactions result in these characteristics. The program has three objectives: (a) the examination of the factors controlling stereoselectivity of reactions of allylmetals with aldehydes and acetals, (b) the clarification of the nature of the intermediates in these reactions, and (c) the design, synthesis and testing of novel Lewis acids for their potential as chiral catalysts. The study involves extensive use of specific model compounds with unique stereochemical centers.

有机合成计划支持斯科特的工作 丹麦，伊利诺伊大学。 丹麦教授的工作 包括研究有机合成的核心反应 和生物化学中的羟醛缩合反应， 具有独特的原子空间取向的化合物。 的 原子在空间中的取向对这两者都有深远的影响。 分子的化学和生物学行为，它是 现代有机化学家所面临的挑战， 反应导致了这些特征。 该方案有三个目标：（a）审查 控制反应的立体选择性的因素 烯丙基金属与醛和缩醛，（B）澄清 在这些反应中的中间体的性质，和（c） 新型刘易斯酸的设计、合成和测试 它们作为手性催化剂的潜力。研究涉及 广泛使用特定的模型化合物， 立体化学中心