Stereochemical Studies in Allylmetal-Aldehyde, -Acetal and Aldol Reactions

有机合成项目支持伊利诺斯大学的斯科特·丹麦的工作。丹麦教授的工作包括研究一个对有机合成和生物化学至关重要的反应，即醛醇缩合，是如何产生具有独特原子空间取向的化合物的。原子的空间取向可以对分子的化学和生物行为产生深远的影响，理解反应如何导致这些特征是现代有机化学家面临的挑战之一。该计划有三个目标：(a)检查控制烯丙基金属与醛和缩醛反应立体选择性的因素，(b)澄清这些反应中中间体的性质，以及(c)设计，合成和测试新型路易斯酸作为手性催化剂的潜力。该研究涉及广泛使用具有独特立体化学中心的特定模型化合物。

The Organic Synthesis Program supports the work of Scott Denmark, of the University of Illinois. Prof. Denmark's work involves examining how a reaction central to organic synthesis and biochemistry, the aldol condensation, can result in compounds with unique spatial orientations of atoms. The orientation in space of atoms can have profound effects on both chemical and biological behavior of molecules, and it is one of the challenges of modern organic chemists to understand how reactions result in these characteristics. The program has three objectives: (a) the examination of the factors controlling stereoselectivity of reactions of allylmetals with aldehydes and acetals, (b) the clarification of the nature of the intermediates in these reactions, and (c) the design, synthesis and testing of novel Lewis acids for their potential as chiral catalysts. The study involves extensive use of specific model compounds with unique stereochemical centers.