POWRE: Self Replicating Peptides

POWRE：自我复制肽

• 批准号: 9806081
• 负责人: Jean Chmielewski
• 金额: $ 7.5万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9806081&HistoricalAwards=false
• 关键词: POWRE; Self; Replicating; Peptides

This award of the Professional Opportunities for Women in Research and Education (POWRE) program funded by the Division of Chemistry supports the research and educational activities of Professor Jean Chmielewski of Purdue University. The research aims to study self-reproducing, autocatalytic as well as cross-catalytic systems in which four peptide fragments will be used to produce four potential coiled-coil products. Amplification of one product over the other will be accomplished by using cross-catalytic peptide templates and by modulating the environmental conditions within the reaction, such as pH or salt concentration. The coiled-coil studies will be extended into the area of self-replicating helix-turn-helix peptides.The opportunity afforded through the POWRE program will enhance Professor Chmielewski's research potential as well as her educational mentoring of undergraduate, graduate, and postdoctoral scientists. The results of this research will allow the PI to pursue a new line of inquiry which falls within the framework of her present research area, self-replicating peptides. Investigation of the self-replicating capabilities of molecules other than DNA and RNA should result in new advances in a wide range of biotechnology disciplines.

该奖项由化学系资助的女性研究和教育专业机会（POWRE）计划支持普渡大学Jean Chmielewski教授的研究和教育活动。 该研究旨在研究自我复制，自催化以及交叉催化系统，其中四个肽片段将用于产生四个潜在的卷曲螺旋产物。 一种产物相对于另一种产物的扩增将通过使用交叉催化肽模板和通过调节反应内的环境条件（例如pH或盐浓度）来实现。 卷曲螺旋研究将扩展到自我复制螺旋-转角-螺旋肽领域。通过POWRE计划提供的机会将增强Chmielewski教授的研究潜力，以及她对本科生，研究生和博士后科学家的教育指导。 这项研究的结果将使PI能够进行一项新的调查，这福尔斯属于她目前的研究领域，自我复制肽的框架。 对DNA和RNA以外的分子的自我复制能力的研究应能在广泛的生物技术学科中取得新的进展。