POWRE: Self Replicating Peptides

这项由化学系资助的女性研究和教育专业机会(POWRE)项目的奖项支持普渡大学Jean Chmielewski教授的研究和教育活动。这项研究旨在研究自复制、自催化以及交叉催化系统，在这些系统中，四个肽片段将被用于生产四个潜在的盘绕产品。通过使用交叉催化的多肽模板和调节反应中的环境条件，如pH或盐浓度，将完成一个产物对另一个产物的放大。螺旋线圈研究将扩展到自我复制螺旋-转角螺旋多肽的领域。通过POWRE计划提供的机会将增强Chmielewski教授的研究潜力以及她对本科生、研究生和博士后科学家的教育指导。这项研究的结果将使PI能够在她目前研究领域的框架内追求一条新的研究路线，即自我复制多肽。对DNA和RNA以外的分子自我复制能力的研究应该会在广泛的生物技术学科中产生新的进展。

This award of the Professional Opportunities for Women in Research and Education (POWRE) program funded by the Division of Chemistry supports the research and educational activities of Professor Jean Chmielewski of Purdue University. The research aims to study self-reproducing, autocatalytic as well as cross-catalytic systems in which four peptide fragments will be used to produce four potential coiled-coil products. Amplification of one product over the other will be accomplished by using cross-catalytic peptide templates and by modulating the environmental conditions within the reaction, such as pH or salt concentration. The coiled-coil studies will be extended into the area of self-replicating helix-turn-helix peptides.The opportunity afforded through the POWRE program will enhance Professor Chmielewski's research potential as well as her educational mentoring of undergraduate, graduate, and postdoctoral scientists. The results of this research will allow the PI to pursue a new line of inquiry which falls within the framework of her present research area, self-replicating peptides. Investigation of the self-replicating capabilities of molecules other than DNA and RNA should result in new advances in a wide range of biotechnology disciplines.