Self Replicating Peptides

自我复制肽

• 批准号: 0447669
• 负责人: Jean Chmielewski
• 金额: $ 46.6万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0447669&HistoricalAwards=false
• 关键词: Self; Replicating; Peptides

This project explores the environmental parameters under which peptide self replication may occur and the types of structural features within peptides that allow for efficient replication. Specific issues being addressed include the control of self replication by cofactors such as metal ions and small molecule ligands and the use of other peptide structures, such as the collagen triple helix motif, for self replication.With this Award, the Organic and Macromolecular Chemistry Program supports the research of Professor Jean A. Chmielewski of Purdue University. Professor Chmielewski studies the self-replication of peptides by analogy with similar work in the area of DNA self-replication that has contributed significantly to the development of biotechnology. In addition to revealing the possible role of peptides in the molecular origins of life, self replicating peptides offer promise in a wide range of technological developments, including self healing materials and sensors.

这个项目探讨了肽自我复制可能发生的环境参数，以及允许有效复制的肽内结构特征的类型。正在解决的具体问题包括控制自我复制的辅因子，如金属离子和小分子配体和使用其他肽结构，如胶原蛋白三螺旋基序，自我replication.With这个奖项，有机和大分子化学计划支持的研究教授让A。普渡大学的Chmielewski。Chmielewski教授通过类比DNA自我复制领域的类似工作来研究肽的自我复制，这对生物技术的发展做出了重大贡献。除了揭示肽在生命分子起源中的可能作用外，自我复制肽还在广泛的技术发展中提供了希望，包括自我修复材料和传感器。