Self Replicating Peptides

该项目旨在将自我复制肽的曲目大幅扩展为新的肽基序，包括具有条件选择潜力的系统。产品抑制的问题将通过使用环境循环和β -片基序来解决。需要解决的具体问题包括对可自我复制的结构基序的限制和对产物抑制的最小化。有了这个奖项，有机和大分子化学项目的有机合成项目支持普渡大学Jean A. Chmielewski教授的研究。Chmielewski教授通过类比DNA自我复制领域的类似工作来研究肽的自我复制，DNA自我复制对生物技术的发展做出了重大贡献。在蛋白质中应用自我复制可以在生物技术方面取得类似的进展。

This project seeks to dramatically expand the repertoire of self replicating peptides into new peptide motifs, including systems with the potential for conditional selection. The problem of product inhibition will be addressed through the use of environmental cycling and beta-sheet motifs. Specific questions to be addressed include the limitations on structural motifs that are amenable to self-replication and the minimization of product inhibition.With this Award, the Organic and Macromolecular Chemistry Program's Organic Synthesis Program supports the research of Professor Jean A. Chmielewski of Purdue University. Professor Chmielewski studies the self-replication of peptides by analogy with similar work in the area of DNA self-replication that has contributed significantly to the development of biotechnology. Application of self-replication in proteins could afford similar advances in biotechnology.