Self Replicating Peptides

自我复制肽

• 批准号: 0078923
• 负责人: Jean Chmielewski
• 金额: $ 39.7万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2003-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078923&HistoricalAwards=false
• 关键词: Self; Replicating; Peptides

This project seeks to dramatically expand the repertoire of self replicating peptides into new peptide motifs, including systems with the potential for conditional selection. The problem of product inhibition will be addressed through the use of environmental cycling and beta-sheet motifs. Specific questions to be addressed include the limitations on structural motifs that are amenable to self-replication and the minimization of product inhibition.With this Award, the Organic and Macromolecular Chemistry Program's Organic Synthesis Program supports the research of Professor Jean A. Chmielewski of Purdue University. Professor Chmielewski studies the self-replication of peptides by analogy with similar work in the area of DNA self-replication that has contributed significantly to the development of biotechnology. Application of self-replication in proteins could afford similar advances in biotechnology.

该项目旨在将自我复制肽的库扩展到新的肽基序，包括具有条件选择潜力的系统。 产物抑制的问题将通过使用环境循环和β-折叠基序来解决。 要解决的具体问题包括对结构基序的限制，这是服从自我复制和最小化的产品inhibit.With这个奖项，有机和大分子化学程序的有机合成程序支持教授让A。普渡大学的Chmielewski。 Chmielewski教授通过类比DNA自我复制领域的类似工作来研究肽的自我复制，这对生物技术的发展做出了重大贡献。 在蛋白质中应用自我复制可以在生物技术中取得类似的进展。