Hierarchical Assembly of Peptide Materials

肽材料的分层组装

• 批准号: 2108722
• 负责人: Jean Chmielewski
• 金额: $ 48万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2108722&HistoricalAwards=false
• 关键词: Hierarchical; Assembly; Peptide; Materials

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry, Professor Jean Chmielewski of Purdue University will conduct research building unique structures on a nano- to micro-scale using ball and stick atomic and molecular building blocks. Professor Chmielewski will study how the size and shape of the prepared structures can be controlled by changing the building blocks at a molecular level. These nano- and micro-structures will be developed to ultimately encapsulate protein drugs for delivery to cells, and to make self-healing materials. Professor Chmielewski will continue to diligently train chemistry students and work toward improving the diversity of the chemistry graduate student population at Purdue University. In this way a new generation of diverse scientists will be available to tackle the technological challenges of the 21st century.Gaining a fundamental understanding of the interactions between nanomaterials and biopolymers, such as proteins and nucleic acids, would have a broad impact on a number of applications, from tissue engineering to device fabrication. Overall, the experiments to be conducted under this award seek to expand supramolecular assembly to the study of peptide-based biomaterial hosts with biopolymer guests and examine cells and as self-replicating materials. The intellectual merit of the proposed studies is focused on gaining a firm understanding of the parameters and mechanisms of macromolecular supramolecular assembly within peptide crystals, nanotubes and nanospheres. At the end of the proposed funding period, the Chmielewski team aims to have optimized conditions for the generation of distinct peptide nano- and microstructures on demand and a basic understanding of the mechanistic underpinnings of the supramolecular assembly process. Key areas of study include the interaction of the peptide nano- and microstructures with biopolymers, and their interactions with cells, and self-replication of these peptide-based structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系大分子，超分子和纳米化学计划的支持下，普渡大学的Jean Chmielewski教授将使用球和棒原子和分子构建块在纳米到微米尺度上进行研究构建独特的结构。Chmielewski教授将研究如何通过在分子水平上改变构建块来控制所制备结构的大小和形状。这些纳米和微米结构将被开发出来，最终封装蛋白质药物，以输送到细胞，并制造自我修复材料。Chmielewski教授将继续努力培养化学专业的学生，并致力于提高普渡大学化学研究生群体的多样性。通过这种方式，新一代的多元化科学家将可以应对21世纪的技术挑战。获得对纳米材料和生物聚合物（如蛋白质和核酸）之间相互作用的基本理解，将对从组织工程到设备制造的许多应用产生广泛的影响。总的来说，根据该奖项进行的实验旨在将超分子组装扩展到基于肽的生物材料宿主与生物聚合物客体的研究，并检查细胞和自我复制材料。所提出的研究的智力价值集中在获得肽晶体，纳米管和纳米球内的大分子超分子组装的参数和机制的深刻理解。在拟议的资助期结束时，Chmielewski团队的目标是根据需求优化生成不同肽纳米和微观结构的条件，并对超分子组装过程的机械基础有基本的了解。主要研究领域包括肽纳米结构和微结构与生物聚合物的相互作用，以及它们与细胞的相互作用，以及这些肽基结构的自我复制。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。