SYMPOSIUM: Cold Spring Harbor Laboratory Course on the Early Development of Xenopus

研讨会：冷泉港非洲爪蟾早期发育实验室课程

• 批准号: 9807918
• 负责人: Terri Grodzicker
• 金额: $ 8.14万
• 依托单位: Cold Spring Harbor Laboratory
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9807918&HistoricalAwards=false
• 关键词: SYMPOSIUM; Cold; Spring; Harbor; Laboratory

Dramatic progress in the field of developmental biology in recent years has resulted from the application of a number of new approaches to classical problems, and led to the need for advanced courses to train new investigators to study those animal models, such as Xenopus, that have been important in making new discoveries in this field. The PI proposes to continue the Cold Spring Harbor Laboratory course on "Early Development of Xenopus laevis", which has now been taught for five years as part of an integrated set of courses at Cold Spring Harbor in a number of areas of modern biology. This course provides extensive laboratory exposure to the biology and manipulation of embryos from the frog Xenopus laevis. Xenopus is a vertebrate uniquely suited for studies of early development, since large numbers of embryos, from fertilization onward, can easily be obtained. Development is rapid and the large size of the embryos facilitates their micromanipulation to allow analysis of such important issues as embryonic inductions, even at the single cell level, that are not feasible in mammalian, avian or fish embryos. The course is suited both for those who have a knowledge of molecular biology and developmental biology, but have had no experience with Xenopus, as well as those with some Xenopus experience who wish to learn newly developed, advanced techniques.

近年来，发育生物学领域的巨大进步源于对经典问题的一些新方法的应用，并导致需要高级课程来培训新的研究人员来研究那些在该领域取得新发现的重要动物模型，如非洲爪哇。国际生物学会建议继续开设冷泉港实验室课程“非洲爪哇的早期发育”，该课程现已教授五年，是冷泉港多个现代生物学领域综合课程的一部分。本课程提供对非洲爪蛙胚胎的生物学和操作的广泛实验室接触。非洲爪哇是一种唯一适合研究早期发育的脊椎动物，因为从受精开始，很容易获得大量的胚胎。胚胎发育迅速，胚胎的大小有助于对胚胎诱导等重要问题进行分析，即使是在单细胞水平上，这些问题在哺乳动物、鸟类或鱼类胚胎中是不可行的。该课程既适合那些对分子生物学和发育生物学有一定了解，但没有非洲爪哇经验的人，也适合那些有非洲爪哇经验但希望学习新开发的先进技术的人。