Upgrade of a 500 MHz Nuclear Magnetic Resonance Spectrometer

500 MHz核磁共振波谱仪的升级

• 批准号: 9808678
• 负责人: J. Devens Gust
• 金额: $ 18万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9808678&HistoricalAwards=false
• 关键词: Upgrade; 500; MHz; Nuclear; Magnetic

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry and Biochemistry at Arizona State University to purchase a nuclear magnetic resonance (NMR) spectrometer console. The console will provide the department with an upgraded 500 MHz NMR spectrometer.This equipment will enhance research in a number of areas such as the following: (1) the study of fundamental processes involved in damage and repair of DNA by proteins, (2) the development of optical probes capable of monitoring conformational changes in single protein and protein/DNA molecules, (3) structural and mechanistic studies of proteins from snake venoms that have long-lasting toxic action on muscle cells, (4) mechanistic studies of chemicals that can lead to selective fragmentation of DNA, and (5)structure determination of glycoproteins that are involved in immune response. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.

该奖项由化学研究仪器和设施 （CRIF）计划将协助化学和生物化学系 在亚利桑那州立大学购买了一台核磁共振仪 (NMR)分光计控制台 控制台将为部门提供 一个升级的500兆赫核磁共振光谱仪。该设备将加强研究 在一些领域，如：（1）基本的研究 参与蛋白质对DNA的损伤和修复的过程，（2） 能够监测构象的光学探针的开发 单个蛋白质和蛋白质/DNA分子的变化，（3）结构和 蛇毒蛋白质的机制研究， 对肌肉细胞的毒性作用，（4）化学物质的机理研究， 可以导致DNA的选择性片段化，以及（5）结构 确定参与免疫应答的糖蛋白。 核磁共振（NMR）光谱是最强大的工具， 化学家用来阐明分子结构的仪器。 它用于识别未知物质，表征特定物质， 分子内原子的排列，并研究 溶液中分子间的相互作用获得最新技术 核磁共振谱是化学家进行前沿研究的基础 research.这些NMR研究的结果在以下领域是有用的， 如聚合物、催化剂和生物学。