NMR Spectroscopy in the Undergraduate Curriculum

核磁共振波谱学在本科课程中的应用

• 批准号: 9850540
• 负责人: Clifford LeMaster
• 金额: $ 10万
• 依托单位: Boise State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9850540&HistoricalAwards=false
• 关键词: NMR; Spectroscopy; Undergraduate; Curriculum

The Chemistry Department is purchasing a wide-bore 300-MHz NMR spectrometer for use in laboratory courses and undergraduate research. Organic chemistry laboratories will use the instrument to identify compounds in reaction sequences, prove the structure of reaction products, and perform qualitative analysis. Proton and l3C spectra will be acquired by students in this course. In the second semester students will learn to use 2-D spectra for confirmation of synthesis products and for qualitative analysis. Organic Chemistry Laboratory will benefit from the automated acquisition and analysis software, which allows quick turnover of samples. Advanced laboratories will build on the basis developed in that course. Physical Chemistry, Biochemistry, and Advanced Chemical Preparations Laboratories will use the spectrometer for new experiments in chemical-shielding trends, thermodynamics, kinetics, relaxation, stereoselectivity of enzyme- catalyzed hydrogen transfer to NAD(P)+, energy transduction in mitochondria, and structure and molecular modeling. The Spectrometric Identification course will teach more advanced techniques such as DEPT, HETEROCOSY, HETCOR, 2-D INADEQUATE, and NOESY. Students will learn to solve real-world unknowns that are sufficiently complex to thwart complete assignment using any one technique. Finally, the undergraduate research component of the Chemistry Major will be significantly enhanced. The new spectrometer will be used by students doing organic and inorganic synthesis tesearch; in studies of the conformational behavior of soil organic matter and its interaction with mineral colloids and pollutants under changing environmental conditions; in gas- and liquid-phase dynamic NMR studies aimed at separating intrinsic and environmental effects on conformational exchange reactions, evaluating theoretical calculations, and generating force-field torsional parameters; and in 3Ip NMR studies that simultaneously determine changes in high-energy phosphate metabolism and cardiac function .

化学系正在购买一台大口径300-MHz核磁共振光谱仪，用于实验室课程和本科生研究。有机化学实验室将使用该仪器识别反应序列中的化合物，证明反应产物的结构，并进行定性分析。在本课程中，学生将获得质子和L3C光谱。在第二学期，学生将学习使用二维光谱来确认合成产品和进行定性分析。有机化学实验室将受益于自动采集和分析软件，这使得样品可以快速周转。先进的实验室将建立在该课程发展的基础上。物理化学、生物化学和高级化学准备实验室将在化学屏蔽趋势、热力学、动力学、弛豫、酶催化的氢转移到NAD(P)+的立体选择性、线粒体中的能量传递以及结构和分子建模等方面使用光谱仪进行新的实验。光谱鉴定课程将教授更高级的技术，如DEPT、HETEROCOSY、HETCOR、2-D不充分和NOESY。学生将学习解决现实世界中的未知数，这些未知数足够复杂，足以阻碍使用任何一种技术完成作业。最后，化学专业的本科生研究部分将得到显著加强。新的光谱仪将用于进行有机和无机合成研究的学生；在不断变化的环境条件下研究土壤有机质的构象行为及其与矿物胶体和污染物相互作用的研究；旨在分离内在和环境对构象交换反应的影响、评估理论计算和产生力场扭转参数的气相和液体动态核磁共振研究；以及同时确定高能磷酸盐代谢和心脏功能变化的3Ip核磁共振研究。