A Cell Culture Core Facility and Equipment for InvestigativeExperiments in Cell Biology for the Undergraduate Curriculum

由于细胞研究在现代生物科学中扮演着核心的、综合的角色，因此，本科阶段接触细胞生物学的现代方法对于良好的生物学或生化教育至关重要。目前，我们的实验室课程缺少现代细胞研究的重要方面。我们建议通过购买设备来解决这个问题，这些设备将允许增加基于调查的实验室，利用细胞培养，从根本上改善生物和化学部门的入门和高级课程。使用体外培养的细胞可以很容易地接近许多迷人的现象，并且创新的实验室添加将为学生提供在当前细胞生物学令人兴奋的领域进行实验的新机会，包括活细胞动态过程的研究。这些活动将提供对各种细胞机制的深刻见解，并将激发学生对细胞研究与不同学科的相关性的认识。这应该会引导更多的学生考虑细胞生物科学的职业道路。除了在正式的实验课上使用外，建议的设备还将进一步用于学生的荣誉研究、学年的独立研究和夏季研究。因此，这个项目将使我们能够填补课程中的重要空白，并扩大凯尼恩大学本科研究的范围。该项目将由来自生物系和化学系的四名教师组成的团队实施。我们计划对新实验室进行全面评估，并通过印刷和电子媒体广泛传播成功的实验。在学生生成数据的新应用中，我们将与学生持续参与，创建在线笔记本，允许任何有WWW访问权限的个人进行调查，模仿我们学生的经历。我们期望我们的传播努力不仅会导致我们的一些实验室的模拟，而且会激发对令人兴奋的细胞现象的远程，虚拟调查。因此，本课题具有广泛应用于生物教学的潜力。

Undergraduate exposure to modern methods in cell biology is crucial to a sound biological or biochemical education because of the central, integrative role that cellular studies play in modern bioscience. At present, important aspects of modern cellular studies are missing from our laboratory curriculum. We propose to remedy this by the purchase of equipment that would allow the addition of investigation-based labs that utilize cell culture, substantively improving courses in the biology and chemistry departments at both the introductory and advanced levels. Many fascinating phenomena are readily approached using cells grown in vitro, and innovative lab additions will afford students new opportunities to conduct experiments in exciting areas of current cell biology, including investigations of dynamic processes in live cells. These activities will furnish striking insights into various cellular mechanisms, and will kindle student awareness of the relevance of cellular studies to diverse disciplines. This should lead more students to consider career paths in cellular bioscience. In addition to use in formal laboratory classes, proposed equipment will see further student use in honors research, independent research during the academic year, and summer research. This project will thus allow us to fill important gaps in our curriculum, and also to broaden the scope of undergraduate research at Kenyon. The project will be implemented by a team of four faculty from the biology and chemistry departments. We plan thorough evaluation of new labs and extensive dissemination of successful experiments through print and electronic media. In a novel use of student-generated data, we will with ongoing student involvement, create online notebooks that will allow any individual with WWW access to conduct investigations that mimic our students' experiences. We expect that our dissemination efforts will not only lead to emulation of some of our labs, but will stimulate remote, virtual investigations of exciting cellular phenomena. Hence, this project has potential to furnish widely-used improvements in biology education.