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ME: Metabolic Engineering of Solvent Tolerance in Anaerobic Bacteria

ME: Metabolic Engineering of Solvent Tolerance in Anaerobic Bacteria
ME：厌氧细菌溶剂耐受性的代谢工程
批准号：
9911231
负责人：
Eleftherios Papoutsakis
金额：
$34.42万
依托单位：
Northwestern University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-07-01 至 2003-08-31
来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9911231&HistoricalAwards=false
关键词：
MEMetabolicEngineeringSolventTolerance

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英文摘要
The objective of this project is to understand the molecular basis of solvent tolerance in Clostridium acetobutylicum, with the purpose of using this information to obtain strains that produce higher concentrations of solvents. The research is organized around two hypotheses: (1) that the ability to produce high concentrations of solvent (butanol), and also butanol tolerance, is enhanced by increased protein stability in strains that overexpress heat-shock proteins; and (2) that butanol tolerance is enhanced by expression of native solvent/drug resistance genes, e. g. proteins of the multidrug efflux family. This project is being jointly funded by two programs at NSF and by the Environmental Protection Agency (EPA).
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    $50.0万
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国内基金
海外基金
丝氨酸/甘氨酸/一碳代谢网络（SGOC metabolic network）调控炎症性巨噬细胞活化及脓毒症病理发生的机制研究
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  • 项目类别：
    重点项目
  • 资助金额：
    305.0万元
  • 批准年份：
    2019
  • 负责人：
    王迪
  • 依托单位：
    浙江大学