Acquisition of a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

傅里叶变换离子回旋共振质谱仪的获取

• 批准号: 9977309
• 负责人: John Eyler
• 金额: --
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-10-01 至 2001-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9977309&HistoricalAwards=false
• 关键词: Acquisition; Fourier; Transform; Ion; Cyclotron

This award from the Chemistry Research Instrumentation and Facilities (CRIF) and the Major Research Instrumentation (MRI) Programs will enable the Department of Chemistry at the University of Florida to acquire a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FTICR-MS). This equipment will enhance research studies in the following areas: 1) protein and nucleic acid structure and biochemistry; 2) in vitro selection with an expanded genetic alphabet; 3) enzyme-substrate complexes and isotope effects in trans-Sialidase; 4) expression of trans-sialidase; 5) synthesis of substrates and isotopomers; 6) novel neuropeptides and their function; and 7) three-fold symmetric supramolecular structures for selective recognition.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules.

化学研究仪器和设施（CRIF）和主要研究仪器（MRI）计划的这一奖项将使佛罗里达大学化学系能够获得傅里叶变换离子回旋共振质谱仪（FTICR-MS）。这一设备将加强以下领域的研究：⑴蛋白质和核酸结构和生物化学; 2）用扩大的遗传字母表进行体外选择; 3）转唾液酸酶中的酶-底物复合物和同位素效应; 4）转唾液酸酶的表达; 5）底物和同位素异构体的合成; 6）新的神经肽及其功能;质谱（MS）是一种用于探测紧密结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。