Electro-active and migratory peptides in lipid bilayers: NMR and biophysical studies

脂质双层中的电活性和迁移肽：NMR 和生物物理研究

• 批准号: DP0986316
• 负责人: Prof Jamie Vandenberg
• 金额: $ 33.24万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-05-20 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0986316
• 关键词: Electro; active; migratory; peptides; lipid

All living things are characterized by the separation of inner space from the surrounding medium by a self-assembling membrane. Selective entry and exit of water, ions and solutes is a defining feature of each type of cell. Some proteins sense the voltage difference across the cell membrane and open or close in response to voltage changes. Others, like bacterial toxins assemble in the membrane as pores, while other peptides migrate across the membrane piggy-backing their peptide cargo. The aim is to understand the molecular mechanisms in examples of these membrane-active peptides and proteins with a view to enabling rational intervention into their operation in situ in normal and disease states.

所有生物的特征都是通过自组装膜将内部空间与周围介质分离。水、离子和溶质的选择性进入和离开是每种类型细胞的定义特征。一些蛋白质感知跨细胞膜的电压差，并响应电压变化而打开或关闭。其他的，如细菌毒素在膜上组装成孔，而其他肽则携带肽货物穿过膜。目的是了解这些膜活性肽和蛋白质的分子机制，以便在正常和疾病状态下对其原位操作进行合理干预。