Structural basis of gating in hERG potassium ion channel proteins

hERG 钾离子通道蛋白门控的结构基础

• 批准号: DP200102540
• 负责人: Prof Jamie Vandenberg
• 金额: $ 33.54万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102540
• 关键词: Structural; basis; gating; hERG; potassium

This project aims to use cryo-electron microscopy to determine atomic resolution structures of open, closed and inactivated states of an ion channel important for regulating activity in the heart and the brain. This work will provide fundamental insights into how ion channel proteins utilise electrochemical energy to mechanically open and close gates that regulate ion flow across cell membranes. Electrical signalling is ubiquitous in biology but is of particular importance in the brain and heart where ion channels are important therapeutic targets for cardiovascular and psychiatric diseases.

该项目旨在使用低温电子显微镜来确定离子通道的开放、关闭和失活状态的原子分辨率结构，离子通道对调节心脏和大脑的活动很重要。这项工作将为离子通道蛋白如何利用电化学能量来机械地打开和关闭调节离子流过细胞膜的门提供基本的见解。电信号在生物学中无处不在，但在大脑和心脏中尤为重要，其中离子通道是心血管和精神疾病的重要治疗靶点。