Dynamics of hERG inactivation gating

hERG 失活门控动力学

• 批准号: nhmrc : 635520
• 负责人: Prof Jamie Vandenberg
• 金额: $ 33.5万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dynamics-herg-inactivation-gating/97840
• 关键词: Dynamics; hERG; inactivation; gating

The hERG potassium ion channel is critical for the maintenance of the normal rhythm of the heartbeat. The aim of this study is to map the temporal sequence of the movements of different parts of the hERG K+ channel that regulate the opening and closing of the extracellular gate of the channel. To achieve this, we will use the powerful protein engineering technique of phi-value analysis, a technique that has never before been applied to voltage-gated ion channels.

hERG钾离子通道对于维持正常的心跳节律至关重要。本研究的目的是绘制hERG K+通道的不同部分的运动的时间序列，这些部分调节通道的细胞外门的打开和关闭。为了实现这一点，我们将使用强大的蛋白质工程技术的φ值分析，一种技术，以前从未被应用于电压门控离子通道。