HERG K+ channels: Molecular basis of gating

HERG K 通道：门控的分子基础

• 批准号: nhmrc : 209547
• 负责人: Prof Jamie Vandenberg
• 金额: $ 29.12万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/herg-k-channels-basis-gating/99021
• 关键词: HERG; K+; channels; Molecular; basis

The rhythm of the normal heart beat is controlled by electrical signals mediated by the flow of ions. The movement of ions across heart cell membranes is predominantly mediated by ion channel proteins. One of these proteins, called HERG, has some very unusual properties that make it well suited for suppressing abnormal heart beats. We propose to undertake a detailed investigation of the mechanisms by which HERG channels open and close. The results will provided a greater understanding of how HERG channels work and how altered function of HERG channels in patients with heart disease leads to an increased risk of abnormal heart rhythms and sudden cardiac death.

正常心跳的节律是由离子流动调节的电信号控制的。离子在心肌细胞膜上的运动主要是由离子通道蛋白介导的。其中一种名为HERG的蛋白质具有一些非常不寻常的特性，使其非常适合抑制异常心跳。我们建议对HERG通道打开和关闭的机制进行详细的研究。这一结果将使我们更好地了解HERG通道是如何工作的，以及心脏病患者HERG通道功能改变如何导致异常心律和心脏性猝死风险增加。