State-dependence of drug binding to hERG K+ channels.

药物与 hERG K 通道结合的状态依赖性。

• 批准号: nhmrc : 573714
• 负责人: Prof Jamie Vandenberg
• 金额: $ 26.49万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/state-dependence-drug-k-channels/100493
• 关键词: State; dependence; drug; binding; hERG

In recent years, it has become apparent that a wide range of prescription drugs can cause inadvertent inhibition of a potassium channel in the heart known as hERG, resulting in an increased risk of cardiac arrhythmias and death. This has prompted the withdrawal from the market of 9 drugs and the introduction of mandatory testing of all drugs for inhibition of hERG channels. In this proposal we seek a molecular explanation for the promiscuity of drug binding to hERG channels

近年来，很明显，广泛的处方药可能会导致心脏中钾通道（称为hERG）的意外抑制，导致心律失常和死亡的风险增加。这促使9种药物退出市场，并对所有抑制hERG通道的药物进行强制性检测。在这个建议中，我们寻求药物与hERG通道结合的混杂性的分子解释