Defective Tracfficking Of HERG K+ Channels: Risk Stratification in Patients With Long QT Syndrome Type 2.

HERG K 通道的缺陷性转运：2 型长 QT 综合征患者的风险分层。

• 批准号: nhmrc : 573715
• 负责人: Prof Jamie Vandenberg
• 金额: $ 32.23万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defective-tracfficking-herg-type-2/77949
• 关键词: Defective; Tracfficking; HERG; K+; Channels

Disturbances of the rhythm of the heartbeat are a major cause of death and disability. Due to the sudden onset and rapidity of death with cardiac arrhythmias it is important to be able to predict in advance who is most at risk. In this study we will investigate whether it is possible to develop in vitro assays to stratify risk in patients with congenital long QT syndrome type 2, an inherited arrhythmia syndrome.

心跳节律紊乱是死亡和残疾的主要原因。由于心律失常的突然发作和快速死亡，因此能够提前预测谁的风险最大是很重要的。在这项研究中，我们将调查是否有可能开发体外分析，以分层的风险，先天性长QT综合征2型，遗传性心律失常综合征患者。