The biology, structure and function of bacterial virulence effectors

细菌毒力效应子的生物学、结构和功能

• 批准号: FT0990267
• 负责人: Prof Elizabeth Hartland
• 金额: $ 56.26万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-04 至 2014-01-03
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0990267
• 关键词: biology; structure; function; bacterial; virulence

This project is closely aligned with the National Research Priority of Promoting and Maintaining Good Health and will establish a research framework to investigate novel virulence processes that allow bacterial pathogens to infect humans and cause disease. This fresh approach to the study of bacterial pathogenesis will sit outside classic genetic methods to investigate infection and immunity which rely heavily on genetic manipulation of the pathogen. Other than providing fundamental information on host-pathogen interactions, this work may lead to novel disease interventions by inhibition of bacterial virulence factor activity and/or enhancement of host inflammatory and immune responses.

该项目与促进和保持良好健康的国家研究优先事项密切相关，并将建立一个研究框架，以调查允许细菌病原体感染人类并导致疾病的新毒力过程。这种研究细菌致病机理的新方法将超越传统的遗传方法，以研究严重依赖病原体遗传操作的感染和免疫。除了提供关于宿主-病原体相互作用的基本信息之外，这项工作可能通过抑制细菌毒力因子活性和/或增强宿主炎症和免疫反应来导致新的疾病干预。