Ubiquitination in Legionella infection

军团菌感染中的泛素化

• 批准号: nhmrc : 1098820
• 负责人: Prof Elizabeth Hartland
• 金额: $ 34.37万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ubiquitination-legionella-infection/662399
• 关键词: Ubiquitination; Legionella; infection

Legionella bacteria are the major cause of Legionnaire’s Disease, a common form of acute pneumonia. Here we will study how the bacteria avoid killing in human cells by establishing an intracellular niche that is sequestered from the normal host cell defence pathways. In particular we hope to understand how the bacteria regulate a major protein modification pathway called ubiquitination.

退伍军人症是一种常见的急性肺炎，退伍军人杆菌是其主要病因。在这里，我们将研究细菌如何通过建立一个与正常宿主细胞防御途径隔离的细胞内小生境来避免对人类细胞的杀伤。特别是，我们希望了解细菌如何调节称为遍在化的主要蛋白质修饰途径。