Glycosyltransferase effectors from bacterial enteric pathogens

细菌肠道病原体的糖基转移酶效应子

• 批准号: nhmrc : 1098826
• 负责人: Prof Elizabeth Hartland
• 金额: $ 53.15万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glycosyltransferase-effectors-bacterial-enteric-pathogens/662400
• 关键词: Glycosyltransferase; effectors; bacterial; enteric; pathogens

Many disease-causing microbes subvert host cell defences to establish infection in part by transporting virulence proteins, termed “effector” proteins, into host cells via specialized protein secretion systems. We have discovered a new family of bacterial effectors that modify host proteins with a sugar and thereby inactivate them. Here we will characterise the function of these effector proteins during infection with E. coli and Salmonella.

许多致病微生物颠覆宿主细胞的防御系统，部分是通过特殊的蛋白质分泌系统将被称为“效应器”的毒力蛋白输送到宿主细胞中，从而建立感染机制。我们发现了一个新的细菌效应物家族，可以用糖修饰宿主蛋白，从而使它们失活。在这里，我们将描述这些效应蛋白在感染大肠杆菌和沙门氏菌过程中的功能。