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Novel bacterial cysteine proteases targeting innate immunity

Novel bacterial cysteine proteases targeting innate immunity
针对先天免疫的新型细菌半胱氨酸蛋白酶
批准号:
nhmrc : 1100609
负责人:
Prof Elizabeth Hartland
金额:
$54.86万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2019-12-31

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中文摘要
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英文摘要
Host innate defence relies on the activation of several signalling pathways that regulate inflammation and cell death. Several important bacterial pathogens of humans inject virulence “effector” proteins into infected cells that interrupt host cell signalling pathways. We recently discovered a family of new effector proteins that directly degrade host proteins and block cell death. Here we will characterise this and other members of the family to understand their role during infection.
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Interferon mediated control of Legionella infection
  • 批准号:
    nhmrc : 1145244
  • 项目类别:
    Project Grants
  • 资助金额:
    $42.52万
  • 财政年份:
    2018
  • 负责人:
    Prof Elizabeth Hartland
  • 依托单位:
Interferon mediated control of Legionella infection
  • 批准号:
    nhmrc : GNT1145244
  • 项目类别:
    Project Grants
  • 资助金额:
    $62.88万
  • 财政年份:
    2018
  • 负责人:
    Prof Elizabeth Hartland
  • 依托单位:
Nucleomodulin effectors of the environmental pathogen Legionella
  • 批准号:
    DP180102725
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $28.97万
  • 财政年份:
    2018
  • 负责人:
    Prof Elizabeth Hartland
  • 依托单位:
Glycosyltransferase effectors from bacterial enteric pathogens
  • 批准号:
    nhmrc : GNT1098826
  • 项目类别:
    Project Grants
  • 资助金额:
    $77.26万
  • 财政年份:
    2016
  • 负责人:
    Prof Elizabeth Hartland
  • 依托单位:
国内基金
海外基金
中国棉铃虫核多角体病毒基因组库和分子进化
  • 批准号:
    30540076
  • 项目类别:
    专项基金项目
  • 资助金额:
    8.0万元
  • 批准年份:
    2005
  • 负责人:
    王汉中
  • 依托单位:
细菌脂蛋白(BLP)诱导LPS交叉耐受的分子机理研究