Novel bacterial cysteine proteases targeting innate immunity
Novel bacterial cysteine proteases targeting innate immunity
批准号:
nhmrc : 1100609
负责人:
Prof Elizabeth Hartland
金额:
$54.86万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2019-12-31
中文摘要
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英文摘要
Host innate defence relies on the activation of several signalling pathways that regulate inflammation and cell death. Several important bacterial pathogens of humans inject virulence “effector” proteins into infected cells that interrupt host cell signalling pathways. We recently discovered a family of new effector proteins that directly degrade host proteins and block cell death. Here we will characterise this and other members of the family to understand their role during infection.
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会议论文
Interferon mediated control of Legionella infection
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批准号:nhmrc : 1145244
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资助金额:$42.52万
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负责人:Prof Elizabeth Hartland
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Interferon mediated control of Legionella infection
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Nucleomodulin effectors of the environmental pathogen Legionella
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批准号:DP180102725
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项目类别:Discovery Projects
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资助金额:$28.97万
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依托单位:
Glycosyltransferase effectors from bacterial enteric pathogens
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批准号:nhmrc : GNT1098826
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资助金额:$77.26万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Glycosyltransferase effectors from bacterial enteric pathogens
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批准号:nhmrc : 1098826
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资助金额:$53.15万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Ubiquitination in Legionella infection
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批准号:nhmrc : GNT1098820
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资助金额:$50.15万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Ubiquitination in Legionella infection
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资助金额:$34.37万
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负责人:Prof Elizabeth Hartland
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依托单位:
Novel bacterial cysteine proteases targeting innate immunity
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批准号:nhmrc : GNT1100609
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项目类别:Project Grants
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资助金额:$79.76万
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财政年份:2016
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依托单位:
Death receptor signaling during E. coli and Salmonella infection
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批准号:nhmrc : 1044061
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资助金额:$39.08万
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财政年份:2013
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负责人:Prof Elizabeth Hartland
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依托单位:
Biology and evolution of intracellular parasitism
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批准号:DP130102689
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项目类别:Discovery Projects
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资助金额:$30.31万
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财政年份:2013
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负责人:Prof Elizabeth Hartland
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依托单位:
The biology, structure and function of bacterial virulence effectors
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批准号:FT0990267
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项目类别:ARC Future Fellowships
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资助金额:$56.26万
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财政年份:2010
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负责人:Prof Elizabeth Hartland
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依托单位:
The intracellular replicative niche of Legionella species and Coxiella burnetii.
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批准号:nhmrc : 566568
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项目类别:NHMRC Project Grants
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资助金额:$35.32万
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负责人:Prof Elizabeth Hartland
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依托单位:
Contribution of nuclear targeting of the NleE-OspZ family of proteins to Escherichia coli and Shigella virulence
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批准号:nhmrc : 566639
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资助金额:$36.17万
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负责人:Prof Elizabeth Hartland
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依托单位:
Host cell targets of bacterial virulence effectors
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批准号:DP0773921
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项目类别:Discovery Projects
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资助金额:$18.25万
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财政年份:2008
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负责人:Prof Elizabeth Hartland
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依托单位:
The host specificity of bacterial pathogens
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批准号:DP0451154
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项目类别:Discovery Projects
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资助金额:$15.67万
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财政年份:2004
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负责人:Prof Elizabeth Hartland
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依托单位:
Identification and characterisation of novel virulence genes in attaching and effacing strains of Escherichia coli
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项目类别:NHMRC Project Grants
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资助金额:$18.76万
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财政年份:2002
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负责人:Prof Elizabeth Hartland
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依托单位:
Characterisation of enterohaemorrhagic Escherichia coli lacking classical virulence markers
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批准号:nhmrc : 194235
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项目类别:NHMRC Project Grants
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资助金额:$9.38万
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财政年份:2002
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负责人:Prof Elizabeth Hartland
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依托单位:
Pathogenesis of infections with enteropathogenic and enterohemorrhagic Escherichia coli
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批准号:nhmrc : 7202
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项目类别:Early Career Fellowships
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资助金额:$3.67万
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财政年份:2000
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负责人:Prof Elizabeth Hartland
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依托单位:
国内基金
海外基金
中国棉铃虫核多角体病毒基因组库和分子进化
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批准号:30540076
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项目类别:专项基金项目
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资助金额:8.0万元
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批准年份:2005
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负责人:王汉中
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依托单位:
细菌脂蛋白(BLP)诱导LPS交叉耐受的分子机理研究
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批准号:30471791
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项目类别:面上项目
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资助金额:20.0万元
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批准年份:2004
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负责人:肖南
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依托单位: