Novel bacterial cysteine proteases targeting innate immunity

针对先天免疫的新型细菌半胱氨酸蛋白酶

• 批准号: nhmrc : 1100609
• 负责人: Prof Elizabeth Hartland
• 金额: $ 54.86万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-bacterial-cysteine-innate-immunity/662519
• 关键词: Novel; bacterial; cysteine; proteases; targeting

Host innate defence relies on the activation of several signalling pathways that regulate inflammation and cell death. Several important bacterial pathogens of humans inject virulence “effector” proteins into infected cells that interrupt host cell signalling pathways. We recently discovered a family of new effector proteins that directly degrade host proteins and block cell death. Here we will characterise this and other members of the family to understand their role during infection.

宿主先天防御依赖于调节炎症和细胞死亡的多种信号通路的激活。人类的几种重要细菌病原体将毒力“效应”蛋白注入受感染的细胞中，从而中断宿主细胞信号传导途径。我们最近发现了一系列新的效应蛋白，可以直接降解宿主蛋白并阻止细胞死亡。在这里，我们将描述该家庭成员和其他家庭成员的特征，以了解他们在感染过程中所扮演的角色。