Death receptor signaling during E. coli and Salmonella infection

大肠杆菌和沙门氏菌感染期间的死亡受体信号传导

• 批准号: nhmrc : 1044061
• 负责人: Prof Elizabeth Hartland
• 金额: $ 39.08万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/death-receptor-signaling-salmonella-infection/111628
• 关键词: Death; receptor; signaling; during; E.

Upon encountering invading microorganisms, the body’s immune system usually initiates an inflammatory response to recruit populations of immune cells to the site of infection. To counter this attack, many bacterial pathogens have evolved distinct ways of disarming the inflammatory response. We are investigating the discovery that gastrointestinal bacteria such as Salmonella and pathogenic E. coli specifically interfere with the messages sent by the body’s innate sensors to recruit killer immune cells.

当遇到入侵的微生物时，身体的免疫系统通常会启动炎症反应，以招募免疫细胞群到感染部位。为了对抗这种攻击，许多细菌病原体已经进化出不同的方式来解除炎症反应。我们正在调查一项发现，即胃肠道细菌，如沙门氏菌和致病性大肠杆菌，会特异性地干扰人体先天传感器发出的信息，从而招募杀伤性免疫细胞。