Interferon mediated control of Legionella infection

干扰素介导的军团菌感染控制

• 批准号: nhmrc : 1145244
• 负责人: Prof Elizabeth Hartland
• 金额: $ 42.52万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interferon-mediated-control-legionella-infection/1320403
• 关键词: Interferon; mediated; control; Legionella; infection

Bacterial lung infections are a serious cause of illness and death in humans. To fight infection the body activates the immune system using a network of signalling molecules. We are studying exactly how one of these signalling molecules called interferon controls the infection. Interferon induces the killing of bacteria that are replicating inside human lung cells. How interferon drives bacterial death is not known and this will be studied in this proposal.

细菌性肺部感染是人类疾病和死亡的严重原因。为了对抗感染，身体使用信号分子网络激活免疫系统。我们正在研究这些信号分子之一干扰素是如何控制感染的。干扰素诱导杀死在人类肺细胞内复制的细菌。干扰素如何驱动细菌死亡尚不清楚，这将在本提案中进行研究。