Glycosyltransferase effectors from bacterial enteric pathogens

细菌肠道病原体的糖基转移酶效应子

• 批准号: nhmrc : GNT1098826
• 负责人: Prof Elizabeth Hartland
• 金额: $ 77.26万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glycosyltransferase-effectors-bacterial-enteric-pathogens/1346011
• 关键词: Glycosyltransferase; effectors; bacterial; enteric; pathogens

Many disease-causing microbes subvert host cell defences to establish infection in part by transporting virulence proteins, termed “effector” proteins, into host cells via specialized protein secretion systems. We have discovered a new family of bacterial effectors that modify host proteins with a sugar and thereby inactivate them. Here we will characterise the function of these effector proteins during infection with E. coli and Salmonella.

许多致病微生物破坏宿主细胞防御以部分地通过经由专门的蛋白质分泌系统将毒力蛋白（称为“效应”蛋白）转运到宿主细胞中来建立感染。我们已经发现了一个新的细菌效应子家族，它可以用糖修饰宿主蛋白质，从而使它们变性。在这里，我们将阐明这些效应蛋白在感染E。大肠杆菌和沙门氏菌。