Contribution of nuclear targeting of the NleE-OspZ family of proteins to Escherichia coli and Shigella virulence
Contribution of nuclear targeting of the NleE-OspZ family of proteins to Escherichia coli and Shigella virulence
批准号:
nhmrc : 566639
负责人:
Prof Elizabeth Hartland
金额:
$36.17万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
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英文摘要
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified new bacterial proteins that allow E. coli to manipulate the normal host cell processes involved in killing an invading bacterium. Similar proteins are also present in the closely related organism, Shigella which causes dysentary. We will determine how these proteins act by finding the host cell proteins they bind.
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依托单位:
国内基金
海外基金
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