Contribution of nuclear targeting of the NleE-OspZ family of proteins to Escherichia coli and Shigella virulence

NleE-OspZ 蛋白家族核靶向对大肠杆菌和志贺氏菌毒力的贡献

• 批准号: nhmrc : 566639
• 负责人: Prof Elizabeth Hartland
• 金额: $ 36.17万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-nuclear-targeting-shigella-virulence/76473
• 关键词: Contribution; nuclear; targeting; NleE; OspZ

This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified new bacterial proteins that allow E. coli to manipulate the normal host cell processes involved in killing an invading bacterium. Similar proteins are also present in the closely related organism, Shigella which causes dysentary. We will determine how these proteins act by finding the host cell proteins they bind.

该项目将研究导致婴儿腹泻的细菌如何在肠道内定植并诱发疾病。我们已经确定了新的细菌蛋白，使大肠杆菌能够操纵正常的宿主细胞过程，从而杀死入侵的细菌。类似的蛋白质也存在于密切相关的生物体中，引起消化不良的志贺氏菌。我们将通过找到这些蛋白质结合的宿主细胞蛋白质来确定这些蛋白质的作用。