Synthetic Methods Based on Nickel Enolates

这项研究的重点包括四个目标：第一，开发涉及金属循环框架内的镍烯醇酸盐的烷基化的催化过程。第二，开发烯醛和炔烃的[3，2]烷基化环加成反应的全合成应用。第三，开发不需要预制的有机金属亲核试剂的共轭加成程序。第四，研究有机锌及相关物种在加速镍催化过程中的作用。通过这一奖项，有机和高分子化学项目支持了约翰·蒙哥马利博士在韦恩州立大学化学系的研究。蒙哥马利教授将把他的工作重点放在新工艺的开发上，这些新工艺包括镍烯醇酸盐的生成和功能化。该研究将促进镍催化、共轭加成化学和过渡金属烯醇化学等领域的发展。该项目有可能在制药行业产生更广泛的影响，该项目是本科生、研究生和博士后的极好培训基地。将强调将代表性不足的少数群体纳入该项目。

The focus of this research involves four goals: First, to develop catalytic processes that involve the alkylation of nickel enolates within a metallacycle framework. Second, to develop total synthesis applications of [3+2] alkylative cycloaddition of enals and alkynes. Third, to develop conjugate addition procedures that do not require preformed organometallic nucleophiles. Fourth, to study the role of organozincs and related species in accelerating the rate of nickel-catalyzed processes. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. John Montgomery in the Department of Chemistry at Wayne State University. Professor Montgomery will focus his work on development of new processes that involve the generation and functionalization of nickel enolates. The research will advance the fields of nickel catalysis, conjugate addition chemistry and transition metal enolate chemistry in general. The project has potential for broader impact in the pharmaceutical industry and the project serves as an excellent training ground for undergraduates, graduate students and postdoctorals. The inclusion of underrepresented minorities to the project will be stressed.