Synthetic Methods Based on Nickel Enolates

本研究的重点包括四个目标：首先，开发涉及金属循环框架内镍烯醇化物烷基化的催化过程。二是开发烯醛和炔的[3+2]烷基化环加成的全合成应用。第三，开发不需要预先形成的有机金属亲核试剂的共轭加成程序。第四，研究有机物和相关物种在加速镍催化过程中的作用。有了这个奖项，有机和大分子化学项目支持韦恩州立大学化学系约翰·蒙哥马利博士的研究。蒙哥马利教授将把他的工作重点放在开发涉及镍烯醇化物的生成和功能化的新工艺上。该研究将推动镍催化、共轭加成化学和过渡金属烯醇酯化学的发展。该项目有可能对制药行业产生更广泛的影响，该项目将成为本科生、研究生和博士后的优秀培训基地。将强调将代表性不足的少数民族纳入该项目。

The focus of this research involves four goals: First, to develop catalytic processes that involve the alkylation of nickel enolates within a metallacycle framework. Second, to develop total synthesis applications of [3+2] alkylative cycloaddition of enals and alkynes. Third, to develop conjugate addition procedures that do not require preformed organometallic nucleophiles. Fourth, to study the role of organozincs and related species in accelerating the rate of nickel-catalyzed processes. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. John Montgomery in the Department of Chemistry at Wayne State University. Professor Montgomery will focus his work on development of new processes that involve the generation and functionalization of nickel enolates. The research will advance the fields of nickel catalysis, conjugate addition chemistry and transition metal enolate chemistry in general. The project has potential for broader impact in the pharmaceutical industry and the project serves as an excellent training ground for undergraduates, graduate students and postdoctorals. The inclusion of underrepresented minorities to the project will be stressed.