SusCHEM: Development of New Reductive Transformations Utilizing First-Row Metal Catalysis

化学部的化学合成计划支持约翰·蒙哥马利教授的研究。蒙哥马利教授是密歇根大学化学系的教员。该项目的目标是开发由富含稀土的金属镍和铜催化的合成有机化学的新工艺。与现有的替代工艺相比，新工艺提供了更好的稳定性和反应性，更低的成本和更容易获得。新的催化剂被用来发现容易获得的底物的新的有机转化。这些努力创造了多功能和高效的新催化剂和合成程序，使高价值产品的创造成为可能。这些产品是以环境可持续的方式从简单和广泛可用的原料中制备的。从事这项工作的学生在新反应的发现、合成方法的开发、有机金属化学和机械化学方面受到培训。研究生的职业发展受到相当大的重视。对本科院校就业感兴趣的研究生有机会在那样的环境中工作。通过与本科院校非常成功的实验室合作，研究生获得了进行研究和指导本科生的经验。其他学生有机会在国际研究实验室进行合作研究。蒙哥马利教授和他的研究团队还参与了外联活动，为底特律大都市区的年轻学生提供接触科学的机会。这些活动影响了包括少数族裔在内的许多年轻学生的学习经历，同时与他们分享了化学领域的兴奋。与贵金属催化剂相比，镍和铜催化剂具有独特的反应性和正交能力。研究的一个主要重点是利用镍和铜的特性反应性来发现和开发其他金属未知的合成工艺，并提供快速获得高价值产品的途径。特别是，硅氧基芳烃是一类未得到充分利用但可广泛获得且价格低廉的有机底物，被广泛应用于各种碳氢、碳硅和碳碳键形成过程中。在涉及铜催化的努力中，通过同时结合多个硼和氰基官能团的方法设计了衍生具有两个或更多不饱和结构单元的底物的新型级联方法。教育计划涉及创新实践，为密歇根大学的研究生提供职业发展培训和国际研究机会。

The Chemical Synthesis Program of the Chemistry Division supports the research by Professor John Montgomery. Professor Montgomery is a faculty member in the Department of Chemistry at the University of Michigan. The goal of this project is to develop new processes for synthetic organic chemistry that are catalyzed by the earth-abundant metals nickel and copper. The new processes offer improved stability and reactivity, lower cost, and ease of access compared with existing alternatives. The new catalysts are being used to discover new organic transformations of readily available substrates. These efforts create versatile and efficient new catalysts and synthetic procedures that enable the creation of high-value products. The products are prepared from simple and widely available feedstocks in an environmentally sustainable manner. Students engaged in the work are trained in the discovery of new reactions, synthetic methods development, organometallic chemistry, and mechanistic chemistry. A substantial emphasis is placed on the career development of graduate students. Graduate students interested in employment at undergraduate institutions have they opportunity to work in that environment. Through a collaboration with a highly successful laboratory at an undergraduate institution, the graduate student gains experience conducting research and mentoring undergraduates. Other students have the opportunity to conduct collaborative research in international research labs.Professor Montgomery and his research team also are involved in outreach activities that provide engaging exposure to science for young students from the Detroit metropolitan area. These activities impact the academic experiences of many young students including underrepresented minorities while sharing with them the excitement of chemistry fields.Compared with precious metal counterparts, nickel and copper catalysts offer unique reactivity and orthogonal capabilities. A primary focus of the research is to capitalize on the characteristic reactivity of nickel and copper to discover and develop synthetic processes that are unknown with other metals and that provide rapid access to high-value products. In particular, silyloxyarenes, which are an underutilized but widely available and inexpensive class of organic substrates, are employed in a wide array of carbon-hydrogen, carbon-silicon, and carbon-carbon bond-forming processes. In efforts involving copper catalysis, novel cascade processes that derivatize substrates possessing two or more unsaturated structural units are devised through processes that simultaneously incorporate multiple boron and cyano functional groups. The education plans involve innovative practices to provide career development training and international research opportunities to graduate students at the University of Michigan.