Redox Control of Transition Metal Catalyzed Processes

过渡金属催化过程的氧化还原控制

• 批准号: 1012270
• 负责人: John Montgomery
• 金额: $ 48万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012270&HistoricalAwards=false
• 关键词: Redox; Control; Transition; Metal; Catalyzed

The general goal of this project is to develop new strategies for the discovery and implementation of transition metal-catalyzed couplings and cycloadditions. The focus will be the development of new approaches for transition metal catalyzed processes that proceed by either net two-electron reduction, or by redox-mediated pathways. While many classes of reductive coupling processes have been developed in recent years, this project aims to develop processes that complement existing methods while improving practicality, cost, and green considerations.With this award, the Chemical Synthesis Program is supporting the research of Professor John Montgomery of the Department of Chemistry at the University of Michigan. Professor Montgomery's research efforts revolve around the discovery of new transition metal-catalyzed chemical transformations, the study of their mechanisms, and their application in the synthesis of complex molecules. The research being studied in this program seeks to provide efficient and environmentally friendly synthetic procedures that allow the rapid synthesis of complex structures from simple precursors. Successes in these areas stand to benefit a variety of important research areas, especially in the pharmaceutical, biotechnology, and agricultural industries.

本项目的总体目标是开发新的策略，用于发现和实施过渡金属催化的偶联和环加成。 重点将是过渡金属催化过程的新方法的发展，进行净两电子还原，或氧化还原介导的途径。 虽然近年来已经开发了许多种类的还原偶联过程，但该项目旨在开发补充现有方法的过程，同时提高实用性，成本和绿色考虑。凭借该奖项，化学合成计划支持密歇根大学化学系的John蒙哥马利教授的研究。蒙哥马利教授的研究工作围绕着新的过渡金属催化的化学转化的发现，其机制的研究，以及它们在复杂分子合成中的应用。该计划正在研究的研究旨在提供高效和环境友好的合成程序，允许从简单的前体快速合成复杂的结构。 这些领域的成功将使许多重要的研究领域受益，特别是在制药、生物技术和农业领域。