CAS: New Strategies for Sustainable Methods in Nickel-Catalyzed Coupling Reactions

有了这个奖项，NSF化学部的化学合成计划正在支持密歇根大学的John蒙哥马利教授的研究。蒙哥马利教授与研究生和本科生一起开发改进的方法来进行有机合成。这些方法涉及确定将简单和容易获得的原料转化为高价值合成化合物的方法，并确定提高合成效率和所开发合成方法的实用性的新催化剂。此外，该方法使用地球上丰富的金属来降低成本并最大限度地减少有害副产物的形成。合成改进可以应用于许多环境，包括学术实验室和制药，生物技术，农业，聚合物和石油工业。教授蒙哥马利是高度致力于包容性的教学实践和创新方式的探索，以整合他的研究，教学和外展重点在他的研究小组。教授蒙哥马利继续与第一代/代表性不足的少数民族学生通过他开发的类工作。更广泛的社会影响包括开展外联活动，提供社区联系，鼓励年轻学生对自己的成功能力充满信心，并在他们的教育道路和职业选择中考虑STEM领域。蒙哥马利教授和他的学生开发新的镍催化剂，使合成工艺的发现和发展，提供快速获得高价值的产品。芳基甲硅烷基醚和烯醇硅烷作为合成中的通用底物的发展使得能够实现新颖的断开，从而为高价值产品结构提供不寻常的和合成上强大的入口。这些方法提供了一个重要的补充，通常采用的加成反应性有机金属亲电羰基。研究的一个组成部分是使用容易获得的，稳定的和高活性的镍（0）催化剂，可以广泛应用于许多研究领域的非专业人士。这些方法可能为有机合成提供新的方法和策略，使快速，高效，选择性和成本效益高的制备高价值structure.This奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor John Montgomery of the University of Michigan. Professor Montgomery works with graduate students and undergraduates to develop improved ways to conduct organic synthesis. The approaches involve identifying ways to convert simple and readily available feedstocks into high value synthetic compounds and to identify new catalysts that improve the synthetic efficiency and practicality of the synthetic methods developed. Additionally, the methods use earth abundant metals to reduce cost and minimize the formation of hazardous by-products. The synthetic improvements can be applied in a number of settings including academic labs and pharmaceutical, biotechnology, agricultural, polymer, and petroleum industries. Professor Montgomery is highly committed to inclusive teaching practices and the exploration of innovative ways to integrate his research, teaching, and outreach focus within his research group. Professor Montgomery continues working with first-generation/underrepresented minority students via a class he developed. Broader societal impacts include development of outreach activities that will provide community connections that encourage young students to be confident in their ability to succeed and to consider STEM fields as they navigate their educational paths and career choices. Professor Montgomery and his students develop new nickel catalysts that enable the discovery and development of synthetic processes that provide rapid access to high-value products. The development of aryl silyl ethers and enol silanes as versatile substrates in synthesis enable novel disconnections that provide unusual and synthetically-powerful entries to high value product structures. These methods provide an important complement to the commonly employed addition of reactive organometallics to electrophilic carbonyls. An integral aspect of the research is the use of readily available, stable, and highly active nickel(0) catalysts that can be broadly applied by non-specialists in many fields of research. The methods may provide new approaches and strategies for organic synthesis that enable the rapid, efficient, selective, and cost-effective preparation of high-value structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.