SusChEM: New Strategies for Catalytic Couplings, Cycloadditions, and Redox Conversions

SusChEM：催化偶联、环加成和氧化还原转化的新策略

• 批准号: 1265491
• 负责人: John Montgomery
• 金额: $ 48万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265491&HistoricalAwards=false
• 关键词: SusChEM; New; Strategies; Catalytic; Couplings

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor John Montgomery of the Department of Chemistry at the University of Michigan will explore the development of methods for transition metal-catalyzed couplings and cycloadditions. Strategies will be developed that enable carbonyl-activated substrates to be utilized in couplings, with deoxygenation occurring during the coupling process. New strategies for the cycloaddition assembly of five-membered rings will also be pursued, with a focus on multicomponent coupling processes. By the proposed strategies, the combination of three simple and widely available components will provide access to a range of structurally complex carbocycles. While some aspects of the specific aims will allow a comparative analysis of nickel and palladium catalysts, the majority of efforts will involve the utilization of inexpensive and readily available nickel catalysts.This work will provide insights into the use of first row metals for the catalytic assembly of complex structures from simple and readily available substrates. New strategies for the development of environmentally benign catalytic processes will be elucidated by these studies. The advances from these studies could be applied to research questions in the pharmaceutical, biotechnology, agricultural, polymer, and petroleum industries. The students engaged in these studies will obtain skills that will enable them to be productive members of these industries or in academic positions at large universities or undergraduate institutions. Student coworkers with an interest in small college academic positions will be given the opportunity to develop collaborative projects with faculty at neighboring institutions.

在这个由化学系化学合成计划资助的项目中，密歇根大学化学系的John蒙哥马利教授将探索过渡金属催化偶联和环加成方法的发展。策略将开发，使羰基活化的底物被用于耦合，与脱氧过程中发生的耦合过程。五元环的环加成组装的新策略也将被追求，重点是多组分偶联过程。通过所提出的策略，三种简单且广泛可用的组分的组合将提供一系列结构复杂的碳环。虽然某些方面的具体目标将允许镍和钯催化剂的比较分析，大部分的努力将涉及利用廉价和容易获得的镍催化剂，这项工作将提供洞察使用的第一行金属的催化组装复杂的结构，从简单和容易获得的基板。这些研究将阐明开发环境友好型催化过程的新策略。这些研究的进展可应用于制药，生物技术，农业，聚合物和石油工业的研究问题。从事这些研究的学生将获得技能，使他们能够成为这些行业的生产成员或在大型大学或本科院校的学术职位。对小型大学学术职位感兴趣的学生同事将有机会与邻近机构的教师开发合作项目。