NUE: Engineering Properties and Micro/Nano Technologies for Biological Systems

这项授予亚利桑那大学的纳米技术本科教育（NUE）奖支持航空航天和机械工程系的Eniko T. Enikov博士和农业和生物系统工程系的Joel Cuello博士开发了一套专注于生物传感器纳米级表面科学的本科实验室实验。生物机械系统和生物传感器引起了极大的兴趣，因为它们在从生物技术和医学诊断到环境监测和生物战的广泛应用中具有潜在的用途。大多数生物传感器的关键部件是能够识别特定分析物分子的人工表面。这项工作将扩展新开发的跨学科本科课程“生物系统的工程特性和微/纳米技术”，通过开发五个实验来支持生物活性表面的纳米工程讲座课程。具体来说，实验将集中在微悬臂探针的制造，有机单层膜（SAMs）的自组装，SAMs的微接触印刷，通过纳米压痕测量生物膜的弹性特性，以及用微悬臂传感器测量自组装单层膜的表面应力。拟议的实验室发展是一个多部门总体计划的一部分，该计划旨在创建一个全校范围的微纳米技术本科课程，不仅满足本科工程专业学生的需求，也满足其他科学专业学生的需求，如生物科学、光学和物理学。它的设计使命是鼓励广泛的学生在纳米技术领域从事科学事业。该奖项的提案是根据纳米科学与工程教育公告（NSF 03-044， NUE类别）收到的，由工程理事会（ENG）和生物科学理事会（BIO）的土木与机械系统司（CMS）和生物工程与环境系统司（BES）共同资助。

This Nanotechnology in Undergraduate Education (NUE) award to the University of Arizona supports Dr. Eniko T. Enikov, Department of Aerospace and Mechanical Engineering, and Dr. Joel Cuello, Agricultural and Biosystems Engineering for their work to develop a set of undergraduate laboratory experiments that are focused on the nano-scale surface science of biosensors. BioMEMS and biosensors have generated significant interest because of their potential use in a wide spectrum of applications ranging from biotechnology and medical diagnostics to environmental monitoring and biological warfare. The key component of most biosensors is an artificial surface capable of recognizing a specific analyte molecule. This effort will expand the newly developed interdisciplinary undergraduate course "Engineering Properties and Micro/Nano Technologies for Biological Systems" through the development of five experiments in support of a lecture-based course on the nanoengineering of biologically active surfaces. Specifically, the experiments will focus on fabrication of micro-cantilever probes, self-assembly of organic monolayers (SAMs), micro-contact printing of SAMs, measurements of elastic properties of bio-films via nano-indentation, and measurement of the surface stress of self-assembled monolayers with micro-cantilever sensors.The proposed laboratory development is part of a multi-departmental master plan for the creation of a college-wide undergraduate curriculum on micro- and nano-technologies addressing the needs not only of undergraduate engineering students but also of students from other sciences, such as biosciences, optics, and physics. It is being designed with the mission of inspiring a broad spectrum of students to pursue scientific careers in the area of nanotechnology. The proposal for this award was received in response to the Nanoscale Science and Engineering Education announcement, NSF 03-044, category NUE and was jointly funded by the Division of Civil and Mechanical Systems (CMS) and the Division of Bioengineering and Environmental Systems (BES) in the Directorate for Engineering (ENG) and the Directorate for Biological Sciences (BIO).