NUE: Engineering Properties and Micro/Nano Technologies for Biological Systems

授予亚利桑那大学本科生教育纳米技术(NUE)奖支持航空航天和机械工程系的Eniko T.Enikov博士和农业与生物系统工程系的Joel Cuello博士，他们致力于开发一套专注于生物传感器纳米尺度表面科学的本科实验室实验。生物微机械系统和生物传感器因其在从生物技术和医学诊断到环境监测和生物战的广泛应用中的潜在应用而引起了人们的极大兴趣。大多数生物传感器的关键部件是能够识别特定分析物分子的人造表面。这项工作将扩展新开发的跨学科本科课程“生物系统的工程特性和微/纳米技术”，通过开发五个实验来支持一门以生物活性表面的纳米工程为基础的讲授课程。具体地说，这些实验将集中在微悬臂梁探针的制造、有机单分子膜(SAM)的自组装、SAM的微接触打印、通过纳米压痕测量生物膜的弹性特性，以及利用微悬臂传感器测量自组装单层膜的表面应力。拟议的实验室发展是一个多部门总体计划的一部分，该计划旨在建立一个大学范围内的微纳技术本科课程，不仅满足本科生的需求，也满足其他学科的学生的需求，如生物科学、光学和物理学。它的设计使命是激励广泛的学生在纳米技术领域追求科学事业。该奖项是根据NSF 03-044纳米级科学和工程教育公告(NSF 03-044，NOE类)收到的，由工程局(ENG)的土木工程和机械系统司(CMS)和生物科学局(BIO)的生物工程和环境系统司(BES)共同资助。

This Nanotechnology in Undergraduate Education (NUE) award to the University of Arizona supports Dr. Eniko T. Enikov, Department of Aerospace and Mechanical Engineering, and Dr. Joel Cuello, Agricultural and Biosystems Engineering for their work to develop a set of undergraduate laboratory experiments that are focused on the nano-scale surface science of biosensors. BioMEMS and biosensors have generated significant interest because of their potential use in a wide spectrum of applications ranging from biotechnology and medical diagnostics to environmental monitoring and biological warfare. The key component of most biosensors is an artificial surface capable of recognizing a specific analyte molecule. This effort will expand the newly developed interdisciplinary undergraduate course "Engineering Properties and Micro/Nano Technologies for Biological Systems" through the development of five experiments in support of a lecture-based course on the nanoengineering of biologically active surfaces. Specifically, the experiments will focus on fabrication of micro-cantilever probes, self-assembly of organic monolayers (SAMs), micro-contact printing of SAMs, measurements of elastic properties of bio-films via nano-indentation, and measurement of the surface stress of self-assembled monolayers with micro-cantilever sensors.The proposed laboratory development is part of a multi-departmental master plan for the creation of a college-wide undergraduate curriculum on micro- and nano-technologies addressing the needs not only of undergraduate engineering students but also of students from other sciences, such as biosciences, optics, and physics. It is being designed with the mission of inspiring a broad spectrum of students to pursue scientific careers in the area of nanotechnology. The proposal for this award was received in response to the Nanoscale Science and Engineering Education announcement, NSF 03-044, category NUE and was jointly funded by the Division of Civil and Mechanical Systems (CMS) and the Division of Bioengineering and Environmental Systems (BES) in the Directorate for Engineering (ENG) and the Directorate for Biological Sciences (BIO).