Synthesis and Development of Shape Selective Reagents

择形试剂的合成与开发

• 批准号: 0414413
• 负责人: Bruce Gibb
• 金额: --
• 依托单位: University of New Orleans
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414413&HistoricalAwards=false
• 关键词: Synthesis; Development; Shape; Selective; Reagents

The focus of this research involves the development of synthetic methods for the production of molecular hosts. The analysis of the hosts will be carried out on two levels. First, they will be studied to gauge the potential for cleaving protecting groups due to cavity shape and the position of functionality within the host compounds. Second, the properties of internally functionalized molecular capsules will be studied. The capsules, formed in water via self-assembly, possess the potential for encapsulating molecules such as steroids in a primarily dry environment.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Bruce C. Gibb in the Department of Chemistry at the University of New Orleans. Dr. Gibb will focus his work for the short term on developing methodology for the synthesis of molecular hosts that possess functionality built into highly concave binding pockets. These readily available hosts will be examined for the ability to cleave common protecting groups. The project will have broader impact as an excellent venue for the training of graduate students, especially those from underrepresented minority groups. Further, the research could have an impact on the pharmaceutical industry.

这项研究的重点是开发生产分子主体的合成方法。对东道主的分析将从两个层面进行。首先，将对它们进行研究，以衡量由于空腔形状和主体化合物中官能团的位置而裂解保护基团的可能性。其次，对内功能化分子胶囊的性质进行了研究。这种胶囊在水中通过自组装形成，具有在主要干燥的环境中包裹类固醇等分子的潜力。凭借这一奖项，有机和高分子化学计划支持新奥尔良大学化学系的布鲁斯·C·吉布博士的研究。吉布博士将在短期内将工作重点放在开发合成分子宿主的方法学上，这些宿主分子具有高度凹陷的捆绑袋中内置的功能。这些容易获得的宿主将被检查是否有能力裂解共同的保护基。该项目将产生更广泛的影响，成为培训研究生，特别是那些来自代表人数不足的少数群体的研究生的极佳场所。此外，这项研究可能会对制药业产生影响。