Supramolecular Design of Novel Reagents and Organo-Catalysts for Aqueous Solution

新型水溶液试剂和有机催化剂的超分子设计

• 批准号: 2305018
• 负责人: Bruce Gibb
• 金额: $ 54.5万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2305018&HistoricalAwards=false
• 关键词: Supramolecular; Design; Novel; Reagents; Organo

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry, Professor Bruce C. Gibb of Tulane University seeks to gain a better understanding of the science of placing molecules within capsules. More specifically, this storage of “guest molecules” will be used to facilitate their chemical transformation into new matter. It is anticipated that understanding these transformations will lead to new efficient and environmentally friendly synthetic methods, and so contribute to the advancement of the chemical enterprise. The described work will not only help train the next generation of chemists, but will also be integrated into community outreach activities to promote STEM (science, technology, engineering and mathematics) education and positively impact the minority population of Orleans Parish and Southern Louisiana.There are two interrelated aims to the work: (a) to contribute to the state-of-the-art of supramolecular chemistry by helping bridge the gap between the field and synthetic methodology, and (b) to achieve the synthesis and exploration of new reagents and catalysts that utilize water and the hydrophobic effect to enable reactions that occur under mild and environmentally benign conditions. Specifically, the work will involve (1) a novel iodination process for aromatic rings to create a mild catalytic process of broad substrate scope; (2) studies into new yoctoliter (10^–24 L) capsules that are negatively charged at low pH and will promote or catalyze reactions involving cationic intermediates and transition states, and (3) the synthesis of new supramolecular capsules possessing endo-functionality — functional groups that are integrated into the walls of the inner-space — that will lead to better control of the bound guest. These three sub-programs aim to help create new supramolecular host-guest complexes and new platforms for organocatalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系中的大分子，超分子和纳米化学计划的支持下，图兰大学的布鲁斯·吉布（Bruce C. Gibb）教授试图更好地了解将分子放入胶囊中的科学。更具体地说，这种“来宾分子”的存储将用于促进其化学转化为新物质。可以预料，了解这些转变将导致新的高效且环保的合成方法，从而有助于化学企业的发展。所描述的工作不仅将有助于培训下一代化学家，而且还将融入社区外展活动中，以促进STEM（科学，技术，工程和数学）教育，并积极影响奥尔良教区和路易斯安那州南部的少数群体人口，对工作有两个相互关联的目标：（a）在构成的综合范围内，构成了综合的概念，并构成了概述的概念，并构成了超级列出的概述，并有效地构成了综合的概念，并有效地构成了综合群体，并有效地构成了综合群体，并有效地构成了综合群体，并构成了超级质量质量的概述，并有助于构成综合的概念。 （b）实现利用水和疏水作用的新试剂和催化剂的合成和探索，以实现在轻度和环境良性条件下发生的反应。具体而言，这项工作将涉及（1）芳族环的新型碘化过程，以创建宽阔的底物范围的轻度催化过程； （2）对新的Yoctoliter（10^–24 L）胶囊的研究，这些胶囊在低pH值下充电，并将促进或催化涉及阳离子中间体和过渡状态的反应，以及（3）新的超分子胶囊的合成，这些超分子胶囊具有内在的范围内，这些内部有范围的内在范围内的范围是范围内的，这是一个范围内的范围，并且是在范围内的范围。这三个子程序旨在帮助创建新的超分子宿主 - 宿主综合体和有机催化的新平台。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被视为通过评估来获得珍贵的支持。