Host-Guest and Catalytic Properties of Deep-Cavity Cavitands

深腔空穴体的主客体和催化特性

• 批准号: 0111133
• 负责人: Bruce Gibb
• 金额: $ 18.2万
• 依托单位: University of New Orleans
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0111133&HistoricalAwards=false
• 关键词: Host; Guest; Catalytic; Properties; Deep

Professor Bruce C. Gibb in the Department of Chemistry at the University of New Orleans is supported by the Organic and Macromolecular Chemistry Program for his studies on the synthesis of resorcinol-based cavitands, determination of binding constants with various small "guest" substrates, incorporation of a Zn(2+) catalytic site into the cavitand, and evaluation of these supramolecular hosts' ability to catalyze the hydrolysis of ester substrates. The regioselective hydrolysis of diester guests based on the characteristics of the binding site will also be explored.With the support of the Organic and Macromolecular Chemistry Program, Professor Gibb will prepare a series of large, cyclic organic compounds which have the capacity to bind to various smaller substrates. A catalytic active site similar to that found in the enzyme, carbonic anhydrase, will then be attached to the cyclic host compound. These enzyme mimics will be evaluated for their ability to catalyze a similar reaction to that of the natural enzyme. By varying the characteristics of the cyclic host's binding cavity, different substrates will be bound to the hosts with varying affinities. This in turn will affect the catalytic rate of these compounds with various substrates.

新奥尔良大学化学系的 Bruce C. Gibb 教授得到了有机和高分子化学项目的支持，他的研究包括基于间苯二酚的空配体的合成、与各种小“客体”底物的结合常数的测定、将 Zn(2+) 催化位点掺入空配体以及评估这些超分子主体催化超分子的能力。 酯底物的水解。 还将探索基于结合位点特征的二酯客体的区域选择性水解。在有机与高分子化学项目的支持下，吉布教授将制备一系列具有与各种较小底物结合能力的大型环状有机化合物。 然后，与酶碳酸酐酶中发现的催化活性位点类似的催化活性位点将连接到环状主体化合物上。 将评估这些酶模拟物催化与天然酶类似反应的能力。 通过改变环状主体结合腔的特征，不同的底物将以不同的亲和力与主体结合。 这反过来会影响这些化合物与各种底物的催化速率。