Host-Guest and Catalytic Properties of Deep-Cavity Cavitands

新奥尔良大学化学系的Bruce C.Gibb教授得到了有机化学和高分子化学计划的支持，他的研究包括间苯二酚基空穴的合成，与各种小的“客体”底物结合常数的测定，空穴中锌(2)催化中心的引入，以及对这些超分子主体催化酯类底物水解的能力的评估。在有机化学和高分子化学计划的支持下，Gibb教授将制备一系列能够与各种较小底物结合的大的环状有机化合物。然后，一个类似于酶中发现的催化活性部位碳酸酐酶将被连接到环状宿主化合物上。这些酶模拟物将被评估它们催化类似于天然酶的反应的能力。通过改变环状宿主结合腔的特征，不同的底物将以不同的亲和力结合到宿主上。这反过来又会影响这些具有不同底物的化合物的催化速率。

Professor Bruce C. Gibb in the Department of Chemistry at the University of New Orleans is supported by the Organic and Macromolecular Chemistry Program for his studies on the synthesis of resorcinol-based cavitands, determination of binding constants with various small "guest" substrates, incorporation of a Zn(2+) catalytic site into the cavitand, and evaluation of these supramolecular hosts' ability to catalyze the hydrolysis of ester substrates. The regioselective hydrolysis of diester guests based on the characteristics of the binding site will also be explored.With the support of the Organic and Macromolecular Chemistry Program, Professor Gibb will prepare a series of large, cyclic organic compounds which have the capacity to bind to various smaller substrates. A catalytic active site similar to that found in the enzyme, carbonic anhydrase, will then be attached to the cyclic host compound. These enzyme mimics will be evaluated for their ability to catalyze a similar reaction to that of the natural enzyme. By varying the characteristics of the cyclic host's binding cavity, different substrates will be bound to the hosts with varying affinities. This in turn will affect the catalytic rate of these compounds with various substrates.