Studies of Deep Cavity Cavitands

新奥尔良大学的Bruce Gibb教授得到化学系大分子、超分子和纳米化学项目的支持，研究水溶液中自组装体系的超分子化学，并设计具有特殊性质的化学复杂体系。这个项目的第一个目标是研究利用选择性分子封装的新的分离协议。在这些体系中，超分子结构封装了复杂化学混合物的选定目标，将它们与整体反应环境隔离开来。第二个目标是设计多(超)分子系统，这种系统缓慢地进化到平衡，并显示出组成和系统的净整体状态之间的不寻常的关系。第三个目标是了解氟相中的超分子化学。拟议的研究调查了在水中形成的纳米胶囊的性质。胶囊将其他分子困在胶囊内部，就像人们熟悉的用于药物配方的胶囊一样，在胶囊内和胶囊外的物质之间产生了物理分离。在分子水平上，这种分离导致了许多不寻常的现象，本研究计划正在研究其中两种现象。它们是：1)实现现有技术无法分离的化学物质的新方法，对生物和饮食科学等领域产生影响；2)整体性质大于其各部分之和的复杂化学体系。复杂系统展示了涌现，或只有通过协同才能产生的性质和现象。生命形式被认为是复杂的系统，拟议的研究将有助于解开不同过程的复杂纠缠。该研究项目将为教育和培训学生，包括代表人数不足的群体的成员提供一个激励的研究环境。

Professor Bruce Gibb at the University of New Orleans is supported by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division to study the supramolecular chemistry of self-assembling systems in aqueous solution and to devise chemically complex systems possessing unusual properties. The first aim of this project is to investigate new separation protocols that utilize selective molecular encapsulation. In these systems, supramolecular structures encapsulate selected targets of complex chemical mixtures, isolating them from the bulk reactive environment. The second aim is to devise multi-(supra)molecular systems that evolve to equilibrium slowly and demonstrate unusual relationships between the components and the net overall state of the system. The third aim focuses on understanding supramolecular chemistry in the fluorous phaseThe proposed studies investigate the properties of nano-sized capsules that are formed in water. The capsules trap other molecules within their interior and, much like familiar capsules for drug formulations, engender a physical separation between what is within the capsule and what lies outside. At the molecular level this separation leads to many unusual phenomena, two of which are being investigated in this program of study. They are: 1) New ways to bring about the separation of chemicals that cannot be separated by current technologies, with impact in areas such as biological and dietary science; 2) Complex chemical systems whose overall properties are greater than the sum of their parts. Complex systems demonstrate emergence, or properties and phenomena that only arise through synergism. Life-forms are considered complex systems, and the proposed studies will aid in disentangling the complex intertwining of different processes. The research project will offer a stimulating research environment for the education and training of students, including members of the underrepresented groups.