Studies of Deep Cavity Cavitands

深腔空穴体的研究

• 批准号: 1244024
• 负责人: Bruce Gibb
• 金额: $ 38.59万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-31 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1244024&HistoricalAwards=false
• 关键词: Studies; Deep; Cavity; Cavitands

Professor Bruce Gibb at the University of New Orleans is supported by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division to study the supramolecular chemistry of self-assembling systems in aqueous solution and to devise chemically complex systems possessing unusual properties. The first aim of this project is to investigate new separation protocols that utilize selective molecular encapsulation. In these systems, supramolecular structures encapsulate selected targets of complex chemical mixtures, isolating them from the bulk reactive environment. The second aim is to devise multi-(supra)molecular systems that evolve to equilibrium slowly and demonstrate unusual relationships between the components and the net overall state of the system. The proposed studies investigate the properties of nano-sized capsules that are formed in water. The capsules trap other molecules within their interior and, much like familiar capsules for drug formulations, engender a physical separation between what is within the capsule and what lies outside. At the molecular level this separation leads to many unusual phenomena, two of which are being investigated in this program of study. They are: 1) New ways to bring about the separation of chemicals that cannot be separated by current technologies, with impact in areas such as biological and dietary science; 2) Complex chemical systems whose overall properties are greater than the sum of their parts. Complex systems demonstrate emergence, or properties and phenomena that only arise through synergism. Life-forms are considered complex systems, and the proposed studies will aid in disentangling the complex intertwining of different processes. The research project will offer a stimulating research environment for the education and training of students, including members of the underrepresented groups.

新奥尔良大学的 Bruce Gibb 教授在化学系的高分子、超分子和纳米化学项目的支持下，研究水溶液中自组装系统的超分子化学，并设计出具有不寻常性质的化学复杂系统。该项目的首要目标是研究利用选择性分子封装的新分离方案。在这些系统中，超分子结构封装了复杂化学混合物的选定目标，将它们与本体反应环境隔离。第二个目标是设计多（超）分子系统，该系统缓慢演化至平衡​​，并展示组件与系统净整体状态之间的不寻常关系。拟议的研究调查了在水中形成的纳米胶囊的特性。胶囊将其他分子捕获在其内部，就像熟悉的药物制剂胶囊一样，在胶囊内部和外部之间产生物理分离。在分子水平上，这种分离导致了许多不寻常的现象，本研究计划正在研究其中两个现象。它们是： 1) 分离现有技术无法分离的化学品的新方法，对生物和饮食科学等领域产生影响； 2）复杂的化学体系，其整体性质大于其各部分性质之和。复杂系统展示了只有通过协同作用才能出现的出现或属性和现象。生命形式被认为是复杂的系统，拟议的研究将有助于理清不同过程之间复杂的交织关系。该研究项目将为学生（包括代表性不足群体的成员）的教育和培训提供一个激励性的研究环境。