Acquisition of a 600-MHz NMR Spectrometer for Biomolecular and Materials Research

购买 600 MHz NMR 波谱仪用于生物分子和材料研究

• 批准号: 0421374
• 负责人: Mei Hong
• 金额: --
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0421374&HistoricalAwards=false
• 关键词: Acquisition; 600; MHz; NMR; Spectrometer

This award provides partial support for the acquisition of a 600 MHz nuclear magnetic resonance (NMR) spectrometer to be used for multidisciplinary research projects, including: (1) membrane protein structure and dynamics, (2) polymeric and catalytic materials studies, (3) molecular mechanism of cell signaling, (4) plant metabolite levels and metabolic fluxes, and (5) chemical reaction kinetics. The instrument will provide enhanced sensitivity and resolution capabilities, and advanced NMR methods not currently available to Iowa State University researchers. The increased sensitivity and resolution of the 600 MHz NMR will critically enable the implementation and development of novel 2D and 3D solid-state NMR correlation techniques for studying membrane protein conformational changes and supramolecular structures. The instrument will dramatically advance cutting-edge research into the structure-property relations of modern catalysts and complex polymers, and will facilitate multi-dimensional heteronuclear solution NMR experiments that interrogate proteins involved in biological signal transmission. Additionally, the NMR will vitalize the construction of metabolic flux maps for plant metabolic engineering. The 600 MHz NMR will benefit a large user base at ISU, engaged in diverse research areas ranging from biodegradable polymers to enzyme kinetics, from plant carbohydrates to self-assembled metal complexes. Students and faculty from smaller neighboring institutions will participate in research and training on the high-field instrument, as well as students from the Research Experiences for Undergraduates (REU) and Minority Engineering Apprenticeship (MEAP) programs.

该奖项为获得600 MHz核磁共振（NMR）光谱仪提供部分支持，用于多学科研究项目，包括：（1）膜蛋白结构和动力学，（2）聚合物和催化材料研究，（3）细胞信号传导的分子机制，（4）植物代谢物水平和代谢通量，以及（5）化学反应动力学。该仪器将提供增强的灵敏度和分辨率能力，以及爱荷华州州立大学研究人员目前无法使用的先进核磁共振方法。600 MHz NMR的灵敏度和分辨率的提高将使新型2D和3D固态NMR相关技术的实施和发展成为可能，用于研究膜蛋白构象变化和超分子结构。该仪器将极大地推进对现代催化剂和复杂聚合物的结构-性能关系的前沿研究，并将促进多维异相溶液NMR实验，以询问参与生物信号传输的蛋白质。 此外，核磁共振将为植物代谢工程的代谢通量图的构建注入活力。 600 MHz NMR将使ISU的庞大用户群受益，这些用户从事从生物可降解聚合物到酶动力学，从植物碳水化合物到自组装金属络合物等各种研究领域。 来自较小的邻近机构的学生和教师将参加高场仪器的研究和培训，以及来自本科生研究经验（REU）和少数民族工程学徒（MEAP）计划的学生。