NSF/FDA Scholar in Residence: Influence of Blood Flow on Temperature Rise in Rescontructed Vasculatures during High-Intensity Focused Ultrasound

巴纳杰高强度聚焦超声(HIFU)具有通过肿瘤消融和阻断肿瘤血管来改善癌症治疗的潜力。为了最大限度地发挥HIFU治疗的效果，最大限度地减少对健康组织的损害，通过量化HIFU能量吸收过程中的温度升高和血流特征来预测组织的反应是很重要的。知识上的一个空白是，在患者特定的病理生理条件下，由于超声波束聚焦在大血管附近并在组织中具有不同的血液灌注率，HIFU期间的温度升高尚未被量化。这项NSF-FDA学者常驻建议的具体目标是使用体外、体外和计算模型建立组织温度响应，该模型可以准确地量化大血管中的血流。中心假设是，温度升高可以与不同的HIFU能源相关，同时考虑到组织通过大血管的灌流和对流。这项研究项目结合了生物流体、生物传热学、传质学和生物学，为HIFU的模拟创建了一个虚拟工具，该工具将通过考虑干扰血管的影响来聚焦和优化患者特定几何形状的HIFU。这个多学科的项目涉及工程学、物理学、生物学和生理学等多个科学领域。

0552036BanerjeeHigh-Intensity Focused Ultrasound (HIFU) has the potential to improve cancer treatment through tumor ablation and occlusion of tumor vasculature. In order to maximize the efficacy of HIFU procedures, and to minimize the damage to healthy tissue, it is important to predict tissue response by quantifying temperature rise, in conjunction with characterization of blood flow, during absorption of HIFU energy. A gap in knowledge is that the temperature rise during HIFU has not been quantified during energy absorption for patient-specific patho-physiological conditions having the ultrasound beam focused near a large blood vessel and having variable blood perfusion in tissues.The specific objective of this NSF-FDA Scholar-In-Residence proposal is to establish tissue temperature response using in-vitro, ex-vivo, and computational models, which can accurately quantify blood flow in large vessels. The central hypothesis is that temperature rise can be correlated to variable HIFU energy sources while accounting for tissue perfusion and convection through large vessels. This research project combines biofluids, bioheat transfer, mass transfer, and biology to create a virtual tool for the simulation of HIFU that would focus and optimize HIFU in patient-specific geometries by considering the effects of interfering blood vessels. This multi-disciplinary project involves several scientific fields including Engineering, Physics, Biology, and Physiology.