NSF/FDA Scholar in Residence: Influence of Blood Flow on Temperature Rise in Rescontructed Vasculatures during High-Intensity Focused Ultrasound

NSF/FDA 常驻学者：高强度聚焦超声期间血流对重建脉管系统温度升高的影响

• 批准号: 0552036
• 负责人: Rupak Banerjee
• 金额: --
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0552036&HistoricalAwards=false
• 关键词: NSF; FDA; Scholar; Residence; Influence

0552036BanerjeeHigh-Intensity Focused Ultrasound (HIFU) has the potential to improve cancer treatment through tumor ablation and occlusion of tumor vasculature. In order to maximize the efficacy of HIFU procedures, and to minimize the damage to healthy tissue, it is important to predict tissue response by quantifying temperature rise, in conjunction with characterization of blood flow, during absorption of HIFU energy. A gap in knowledge is that the temperature rise during HIFU has not been quantified during energy absorption for patient-specific patho-physiological conditions having the ultrasound beam focused near a large blood vessel and having variable blood perfusion in tissues.The specific objective of this NSF-FDA Scholar-In-Residence proposal is to establish tissue temperature response using in-vitro, ex-vivo, and computational models, which can accurately quantify blood flow in large vessels. The central hypothesis is that temperature rise can be correlated to variable HIFU energy sources while accounting for tissue perfusion and convection through large vessels. This research project combines biofluids, bioheat transfer, mass transfer, and biology to create a virtual tool for the simulation of HIFU that would focus and optimize HIFU in patient-specific geometries by considering the effects of interfering blood vessels. This multi-disciplinary project involves several scientific fields including Engineering, Physics, Biology, and Physiology.

高强度聚焦超声（HIFU）有可能通过肿瘤消融和肿瘤血管闭塞来改善癌症治疗。为了最大限度地提高HIFU手术的疗效，并尽量减少对健康组织的损害，在HIFU能量吸收过程中，通过量化温升并结合血流特征来预测组织反应是很重要的。知识上的一个空白是，在超声束聚焦在大血管附近且组织中血液灌注变化的患者特异性病理生理条件下，HIFU期间的温升没有被量化。这项NSF-FDA驻校学者提案的具体目标是利用体外、离体和计算模型建立组织温度反应，从而准确量化大血管中的血流。中心假设是温度升高可以与可变的HIFU能量来源相关，同时考虑到组织灌注和通过大血管的对流。该研究项目结合了生物流体、生物传热、传质和生物学，创建了一个模拟HIFU的虚拟工具，通过考虑干扰血管的影响，将HIFU集中在患者特定的几何形状上并进行优化。这个多学科项目涉及多个科学领域，包括工程、物理、生物和生理学。