NSF/FDA Scholar in Residence: Influence of Blood Flow on Temperature Rise in Rescontructed Vasculatures during High-Intensity Focused Ultrasound

0552036Banerjee高强度聚焦超声（HIFU）有可能通过肿瘤消融和肿瘤血管闭塞来改善癌症治疗。为了使HIFU手术的功效最大化，并使对健康组织的损伤最小化，重要的是通过量化HIFU能量吸收期间的温度升高结合血流的表征来预测组织响应。知识上的一个空白是，对于患者特定的病理生理条件，在能量吸收期间，HIFU期间的温度上升尚未被量化，所述患者特定的病理生理条件具有聚焦在大血管附近的超声波束并且在组织中具有可变的血液灌注。其可以精确地量化大血管中的血流。中心假设是，温度升高可以与可变的HIFU能量源相关，同时考虑通过大血管的组织灌注和对流。 该研究项目结合了生物流体，生物传热，传质和生物学，以创建一个用于模拟HIFU的虚拟工具，该工具将通过考虑干扰血管的影响来关注和优化患者特定几何形状的HIFU。这个多学科项目涉及多个科学领域，包括工程学，物理学，生物学和生理学。

0552036BanerjeeHigh-Intensity Focused Ultrasound (HIFU) has the potential to improve cancer treatment through tumor ablation and occlusion of tumor vasculature. In order to maximize the efficacy of HIFU procedures, and to minimize the damage to healthy tissue, it is important to predict tissue response by quantifying temperature rise, in conjunction with characterization of blood flow, during absorption of HIFU energy. A gap in knowledge is that the temperature rise during HIFU has not been quantified during energy absorption for patient-specific patho-physiological conditions having the ultrasound beam focused near a large blood vessel and having variable blood perfusion in tissues.The specific objective of this NSF-FDA Scholar-In-Residence proposal is to establish tissue temperature response using in-vitro, ex-vivo, and computational models, which can accurately quantify blood flow in large vessels. The central hypothesis is that temperature rise can be correlated to variable HIFU energy sources while accounting for tissue perfusion and convection through large vessels. This research project combines biofluids, bioheat transfer, mass transfer, and biology to create a virtual tool for the simulation of HIFU that would focus and optimize HIFU in patient-specific geometries by considering the effects of interfering blood vessels. This multi-disciplinary project involves several scientific fields including Engineering, Physics, Biology, and Physiology.