Materials World Network: Designer Nanodiamonds for Detoxification

材料世界网络：用于排毒的设计师纳米钻石

• 批准号: 0602906
• 负责人: Donald Brenner
• 金额: $ 47.1万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2010-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0602906&HistoricalAwards=false
• 关键词: Materials; World; Network; Designer; Nanodiamonds

We have assembled a multidisciplinary team of Russian and U.S. researchers who are experts in experimental/computational Materials Science and Medical/Agricultural Research. This team will create hydrosols of functionalized diamond nanoparticles that act as designer gastrointestinal enterosorbents for mycotoxins. Mycotoxins, which are the toxic by-products of molds, are a major problem in developing countries where food shortages make disposing of potentially moldy feed impractical. The designer diamond nanoparticles being developed by our team are a completely new and novel set of enterosorbent materials that can be made in bulk quantities and tuned to bind specific toxins while minimizing harmful side effects. The U.S. team is composed of Prof. Don Brenner and Prof. Tzy-Jiun Mark Luo from the Department of Materials Science and Engineering at North Carolina State University, and Dr. Olga Shenderova, Senior Scientist and Dr. Varvara Grichko, Consultant, from the International Technology Center (ITC), Research Triangle Park, NC. The primary role of the U.S. researchers is to use accurate ab initio and molecular modeling methods to efficiently explore diamond nanoparticle surface structures in terms of stability and target multi-functionality, and using a proprietary glow discharge atmospheric plasma experimentally process and then spectroscopically characterize diamond nanoparticles based on the results of the modeling studies. Multi-functionality refers to the ability of the diamond nanoparticles to remain as stable and well dispersed hydro/organosols while yielding biological activity for targeted anti-toxin applications. The lead researchers of the Russian counterpart effort are Dr. Vladimir Bondar and Dr. Alexei Puzur of the Institute of Biophysics (IB), Russian Academy of Sciences, Siberian Branch, Krasnoyarsk, Russia. Dr. Bondars and Dr. Puzurs primary role in our team is to provide size-selected diamond nanoparticles for processing at the ITC, and to carry out the in vitro and in vivo studies of the biological activity, both desirable and harmful, of the materials after processing by the U.S. team. This institute is one of the international leaders in the development and testing of enterosorbents for livestock and human medical uses. As part of this effort we are training a new generation of Materials Science graduate students to perform research at the interface of Materials Science/Medicine/Agriculture, as well as providing these students first-hand experience with how theory, modeling and experiment can interact and aid progress in each area. This effort also gives students experience working within an industrial setting and provides the students with intimate knowledge of technology transfer.

我们组建了一个由俄罗斯和美国研究人员组成的多学科团队，他们是实验/计算材料科学和医学/农业研究方面的专家。该团队将制造功能化金刚石纳米颗粒的水溶胶，作为真菌毒素的胃肠道肠道吸附剂。霉菌毒素是霉菌的有毒副产品，是发展中国家的一个主要问题，在这些国家，粮食短缺使得处理可能发霉的饲料变得不切实际。我们团队正在开发的设计金刚石纳米颗粒是一种全新的、新颖的肠道吸收材料，可以批量生产，并调整以结合特定毒素，同时最大限度地减少有害的副作用。美国团队由北卡罗来纳州立大学材料科学与工程系的Don Brenner教授和Tzy-Jiun Mark Luo教授，以及北卡罗来纳州三角研究园国际技术中心（ITC）的资深科学家Olga Shenderova博士和顾问Varvara Grichko博士组成。美国研究人员的主要作用是使用精确的从头算和分子建模方法来有效地探索金刚石纳米颗粒表面结构的稳定性和目标多功能性，并使用专有的辉光放电大气等离子体实验过程，然后根据建模研究结果对金刚石纳米颗粒进行光谱表征。多功能是指金刚石纳米颗粒在具有生物活性的同时，能够保持稳定和分散良好的水/有机溶胶。俄罗斯同行的主要研究人员是俄罗斯科学院西伯利亚分院生物物理研究所（IB）的Vladimir Bondar博士和Alexei Puzur博士。Bondars博士和Puzurs博士在我们团队中的主要职责是为ITC加工提供尺寸选择的金刚石纳米颗粒，并在美国团队加工后对材料的生物活性（包括有益的和有害的）进行体外和体内研究。该研究所是家畜和人类医疗用吸附剂开发和测试的国际领先机构之一。作为这一努力的一部分，我们正在培养新一代材料科学研究生在材料科学/医学/农业的界面上进行研究，并为这些学生提供第一手的经验，让他们了解理论、建模和实验如何相互作用，并帮助每个领域的进步。这一努力也为学生提供了在工业环境中工作的经验，并为学生提供了技术转移的亲密知识。