NIRT: Molecular electronic devices with carbon-based electrodes on active substrates

NIRT:哥伦比亚大学化学系colin Nuckolls、哥伦比亚大学电子工程系kenneth Shepard、哥伦比亚大学物理系philip Kim、哥伦比亚大学机械工程系乔林、哥伦比亚大学化学系matthew Francis、哥伦比亚大学电子工程系这项研究的目的是开发一种基于分子电子器件的新型纳米级生物传感器，该器件利用碳纳米管和石墨烯基电极。该方法的核心是利用化学方法将生物大分子作为分子桥的识别域，并进一步开发这些分子电子设备作为传感器。这些生物传感器将被制造在有源互补金属氧化物半导体微电子衬底上，以提供真正的单分子灵敏度和潜在的亚微秒时间分辨率。所提出的工作的智力价值集中在使用这种方法可以实现的敏感性和特异性上。由于这些传感器不依赖于时间或集合平均来实现灵敏度，它们在真正的单分子水平上监测单个事件，提供了探测-目标相互作用的丰富随机动力学的测量。特别是，研究工作涉及新的科学研究，涉及核酸杂交，蛋白质蛋白质相互作用和单分子敏感性蛋白质构象变化，对折叠和催化等过程产生新的见解。这些高度集成的设备将在医学诊断（基因组学和蛋白质组学）、药物发现和环境监测方面有广泛的实际应用。这个研究和教育的综合项目在培养跨学科研究环境中的研究生和本科生方面具有广泛的影响。该研究对医学、药理学、半导体、国土安全、环境监测等科学技术领域产生了广泛的影响。通过系统地培训高积极性的高中生，并加强与当地K-12教育工作者的互动，将为K-12的推广做出重大努力。

NIRT: Molecular electronic devices with carbon-based electrodes on active substratesColin Nuckolls, Department of Chemistry, Columbia UniversityKenneth Shepard, Department of Electrical Engineering, Columbia UniversityPhilip Kim, Department of Physics, Columbia UniversityQiao Lin, Department of Mechanical Engineering, Columbia UniversityMatthew Francis, Department of Chemistry, University of California BerkeleyThe objective of this research is to develop a new class of nanoscale biosensors based on molecular electronic devices that utilize carbon nanotube and graphene-based electrodes. The approach centers around using chemistry to incorporate biological macromolecules as recognition domains on molecular bridges and to further develop these molecular-electronic devices as sensors. These biosensors will be fabricated on active complementary metal-oxide-semiconductor microelectronic substrates to provide true single-molecular sensitivities with potentially submicrosecond temporal resolution. The intellectual merit of the proposed effort is centered on the sensitivity and specificity that can be achieved using this approach. Because these sensors do not rely on temporal or ensemble averaging to achieve sensitivity, they monitor individual events at a true single-molecule level, providing measurement of rich stochastic dynamics of probe-target interactions. In particular, the research effort involves new scientific investigations involving nucleic acid hybridization, protein-protein interactions, and protein conformation changes with single-molecule sensitivity, yielding new insight into processes such as folding and catalysis. These highly integrated devices will have broad practical application in medical diagnostics (genomics and proteomics), drug discovery, and environmental monitoring. This integrated program of research and education has broad impact in training graduate and undergraduate students in a cross-disciplinary research environment. The research has broad impact to a range of science and technology including medicine, pharmacology, semiconductors, homeland security, and environmental monitoring. Significant effort will be made for K-12 outreach by systematically training highly motivated high school students within the program and also enhancing the interaction with local K-12 educators.