NIRT: Molecular electronic devices with carbon-based electrodes on active substrates

NIRT：在活性基底上具有碳基电极的分子电子器件哥伦比亚大学化学系Colin Nuckolls哥伦比亚大学电气工程系Kenneth谢泼德哥伦比亚大学物理系Philip Kim哥伦比亚大学机械工程系乔林化学系Matthew弗朗西斯加州伯克利大学本研究的目的是开发一类新的纳米生物传感器的基础上，利用碳纳米管和石墨烯为基础的电极的分子电子器件。该方法的核心是使用化学方法将生物大分子作为分子桥上的识别域，并进一步开发这些分子电子器件作为传感器。这些生物传感器将在有源互补金属氧化物半导体微电子衬底上制造，以提供真正的单分子灵敏度，具有潜在的亚微秒时间分辨率。 所提出的努力的智力价值集中在使用这种方法可以实现的灵敏度和特异性上。 由于这些传感器不依赖于时间或系综平均来实现灵敏度，因此它们在真正的单分子水平上监测单个事件，从而提供对探针-靶相互作用的丰富随机动力学的测量。 特别是，研究工作涉及新的科学调查，涉及核酸杂交，蛋白质-蛋白质相互作用和蛋白质构象变化与单分子灵敏度，产生新的见解，如折叠和催化过程。 这些高度集成的设备将在医学诊断（基因组学和蛋白质组学），药物发现和环境监测方面具有广泛的实际应用。 这种研究和教育的综合计划在跨学科研究环境中培养研究生和本科生具有广泛的影响。该研究对医学、药理学、半导体、国土安全和环境监测等一系列科学和技术产生了广泛的影响。 将在K-12外展方面做出重大努力，在该计划中系统地培训积极主动的高中生，并加强与当地K-12教育工作者的互动。

NIRT: Molecular electronic devices with carbon-based electrodes on active substratesColin Nuckolls, Department of Chemistry, Columbia UniversityKenneth Shepard, Department of Electrical Engineering, Columbia UniversityPhilip Kim, Department of Physics, Columbia UniversityQiao Lin, Department of Mechanical Engineering, Columbia UniversityMatthew Francis, Department of Chemistry, University of California BerkeleyThe objective of this research is to develop a new class of nanoscale biosensors based on molecular electronic devices that utilize carbon nanotube and graphene-based electrodes. The approach centers around using chemistry to incorporate biological macromolecules as recognition domains on molecular bridges and to further develop these molecular-electronic devices as sensors. These biosensors will be fabricated on active complementary metal-oxide-semiconductor microelectronic substrates to provide true single-molecular sensitivities with potentially submicrosecond temporal resolution. The intellectual merit of the proposed effort is centered on the sensitivity and specificity that can be achieved using this approach. Because these sensors do not rely on temporal or ensemble averaging to achieve sensitivity, they monitor individual events at a true single-molecule level, providing measurement of rich stochastic dynamics of probe-target interactions. In particular, the research effort involves new scientific investigations involving nucleic acid hybridization, protein-protein interactions, and protein conformation changes with single-molecule sensitivity, yielding new insight into processes such as folding and catalysis. These highly integrated devices will have broad practical application in medical diagnostics (genomics and proteomics), drug discovery, and environmental monitoring. This integrated program of research and education has broad impact in training graduate and undergraduate students in a cross-disciplinary research environment. The research has broad impact to a range of science and technology including medicine, pharmacology, semiconductors, homeland security, and environmental monitoring. Significant effort will be made for K-12 outreach by systematically training highly motivated high school students within the program and also enhancing the interaction with local K-12 educators.