NER: Ultra-small nanoparticles for thermal therapies at molecular and cellular level

这一提议研究了新型的基于纳米颗粒的治疗方法的基本原理，以灭活传染性病毒的单个拷贝。设想的治疗方法包括活性纳米生物偶联系统，该系统由纳米颗粒选择性地附着在病毒上或被捕获细胞吸收，当受到射频（RF）电磁波时，该捕获细胞会诱导高度局部加热。在本提案中，申请人将研究与超小金颗粒悬浮液和颗粒细胞系统中的热产生和散热机制相关的基本方面。他们将首次测量射频电磁场作用下纳米粒子-生物偶联系统的局部温升。这将是第一步，开创性的一步，以了解纳米生物缀合物的热产生和耗散机制的纳米级性质。

CBET-0708521 Borca-Tasciuc This proposal investigates the fundamentals of novel, nanoparticle basedtreatments to inactivate individual copies of infectious viruses. The envisionedtreatments involve active nano-bioconjugated systems composed of nanoparticlesselectively attached to a virus or ingested by a trap-cell that induce a highly localizedheating when subjected to a radio frequency (RF) electromagnetic wave. In this proposalthe applicants will investigate fundamental aspects related to the heat generation and heat dissipation mechanisms in ultra-small gold particle suspensions as well as particle cell systems. They will measure for the first time the local temperature rise in a nanoparticle-bioconjugatesystem subjected to RF electromagnetic field. This will be a first, pioneering step towardunderstanding nanoscale nature of heat generation and dissipation mechanisms in nanobioconjugated complexes.