NER: Ultra-small nanoparticles for thermal therapies at molecular and cellular level

CBET-0708521 Borca-Tasciuc 该提案研究了基于纳米颗粒的新型治疗方法的基本原理，以消除感染性病毒的个体拷贝。设想的治疗方法包括活性纳米生物共轭系统，该系统由纳米颗粒组成，纳米颗粒选择性地附着在病毒上或被陷阱细胞摄入，当受到射频（RF）电磁波时，该系统会诱导高度局部化的加热。在这个提案中，申请人将研究与超小金颗粒悬浮液以及颗粒细胞系统中的热产生和热耗散机制相关的基本方面。他们将首次测量纳米粒子-生物共轭体系在射频电磁场作用下的局部温升。这将是第一个，开拓性的一步towardunderstanding nanobioconjugated复合物中的热生成和耗散机制的纳米级性质。

CBET-0708521 Borca-Tasciuc This proposal investigates the fundamentals of novel, nanoparticle basedtreatments to inactivate individual copies of infectious viruses. The envisionedtreatments involve active nano-bioconjugated systems composed of nanoparticlesselectively attached to a virus or ingested by a trap-cell that induce a highly localizedheating when subjected to a radio frequency (RF) electromagnetic wave. In this proposalthe applicants will investigate fundamental aspects related to the heat generation and heat dissipation mechanisms in ultra-small gold particle suspensions as well as particle cell systems. They will measure for the first time the local temperature rise in a nanoparticle-bioconjugatesystem subjected to RF electromagnetic field. This will be a first, pioneering step towardunderstanding nanoscale nature of heat generation and dissipation mechanisms in nanobioconjugated complexes.