CAREER:Towards engineering transport properties of nanoparticles for magnetically-mediated hyperthermia applications

0846433 Borca-TasciucThis award is funded under the American Recovery and Reinvestment Act of 2009（Public Law 111-5）.磁加热纳米颗粒被广泛用于癌症热疗研究。然而，目前的努力集中在开发新的磁性纳米颗粒或评估其治疗效果，而没有清楚地了解控制热量产生和耗散的物理机制和关键参数。智力上的优点。将确定控制纳米颗粒悬浮液中的热产生和耗散的关键参数进行磁加热。研究的重点之一是应用于纳米颗粒的分子涂层，以及它们对生热速率和温升的影响。将开发发电的理论模型，以考虑以前忽略的影响，如粒子之间的相互作用。将研究生物系统（细胞培养物），以评估细胞外和细胞介质可能改变纳米颗粒加热效率的程度。这些研究将显示纳米颗粒在细胞内的定位（即细胞核内与细胞膜上的脂筏）如何影响细胞死亡率。新的系统，基于功能化的金基纳米粒子表现出超顺磁性行为，研究热疗应用。一个新的概念，分子热管将被探索，以确定工程的生物共轭纳米粒子系统的热传输的潜力。更广泛的影响。这项研究将推进磁介导的癌症热疗领域，并可能导致新的生物医学程序，如分子手术和基于纳米粒子的基因治疗。此外，将开发一门专注于磁性纳米粒子及其在医学中的应用的课程，采用基于探究的学习方法。一系列外联活动，包括本科生的国际和研究经验，教师的夏季研究经验，以及高中生的演示和动手活动，将针对增加科学和工程中代表性不足的群体的参与。

0846433Borca-TasciucThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Magnetically heated nanoparticles are considered extensively in cancer hyperthermia research. However, current efforts are focused either on developing new magnetic nanoparticles or assessing their therapeutic effects, without a clear understanding of the physical mechanisms and key parameters that control heat generation and dissipation. Intellectual merit. Key parameters controlling heat generation and dissipation in nanoparticle suspensions subjected to magnetic heating will be identified. Among the focal points of the study are the molecular coatings applied to the nanoparticles, and their effect on heat generation rate and temperature rise. Theoretical models for power generation will be developed to account for effects previously neglected such as interactions between particles. Biological systems (cell cultures) will be investigated in order to assess the degree to which extracellular and cellular media may change the heating efficiency of nanoparticles. These studies will show how nanoparticle positioning within the cell (i.e. within the nucleus versus the lipid raft on the cell membrane) affects cell death rate. New systems, based on functionalized gold-based nanoparticles which exhibit superparamagnetic behavior, are investigated for hyperthermia applications. A novel concept of molecular heat pipes will be explored to determine the potential of engineering the heat transport in bioconjugated nanoparticle systems. Broader impact. This research will advance the field of magnetically-mediated cancer hyperthermia and may lead to novel biomedical procedures such as molecular surgery and nanoparticle based gene therapy. Moreover, a course focused on magnetic nanoparticles and their applications in medicine will be developed, employing an inquiry based learning methodology. A series of outreach activities, including international and research experiences for undergraduate students, summer research experiences for teachers, as well as presentations and hands on activities for high school students, will target increasing the participation of underrepresented groups in science and engineering.