MRI: Acquisition of a Liquid Chromatograph Electron Spray Ionization Mass Spectrometer

弗吉尼亚理工学院和州立大学的化学系将获得一个液相色谱电喷雾电离质谱仪（LC-ESI-MS），该奖项来自主要研究仪器计划。 这将用于各种研究项目，包括研究：生物活性天然产品;紫杉醇衍生物;自由基离子和单分子重排;作为疟疾蛋白酶抑制剂的二肽-硼酸;合成方法和药物化学;构象约束肽模拟物;碳纳米材料;作为局部抗感染药的树枝状硫酸盐;分子磁体;捕光超分子组装;准轮烷、轮烷和聚轮烷;大分子合成;高度氟化的Diels-Alder聚亚苯基。质谱是物理和生物科学家使用的基本工具，通过精确测量材料和化学物质在仪器中蒸发和电离时的质量和碎片模式来识别和表征材料和化学物质。 液相色谱法是一种分离技术，在引入质谱仪之前将复杂的混合物分离成单独的组分。 这些都是在青年科学家培训中应采用的重要工具。 该仪器将被本科生和研究生以及博士后在他们的研究中亲自使用。

The Chemistry Department at Virginia Polytechnic Institute and State University will acquire a liquid chromatograph electrospray ionization mass spectrometer (LC-ESI-MS) with this award from the Major Research Instrumentation program. This will be used in a diverse body of research projects including studies of: bioactive natural products; derivatives of paclitaxel; radical ions and unimolecular rearrangements; dipeptide-borinic acids as malarial protease inhibitors; synthetic methods and medicinal chemistry; conformationally constrained peptide mimics; carbonaceous nanomaterials; dendritic sulfates as topical anti-infectives; molecular magnets; light-harvesting supramolecular assemblies; pseudorotaxanes, rotaxanes and polyrotaxanes; macromolecular synthesis; highly fluorinated Diels-Alder polyphenylenes.Mass spectroscopy is a basic tool used by physical and biological scientists to identify and characterize materials and chemical species by accurate measurement of their mass and fragmentation patterns as they are vaporized and ionized in the instrument. Liquid chromatography is an isolation technique that separates a complex mixture into individual components before introduced to the mass spectrometer. These are important tools to be introduced into the training of young scientists. This instrument will be used hands-on by undergraduate and graduate students, and post docs in their research.