MRI: Acquisition of a Liquid Chromatograph Electron Spray Ionization Mass Spectrometer

MRI：购买液相色谱电子喷雾电离质谱仪

• 批准号: 0722638
• 负责人: Paul Deck
• 金额: $ 23.52万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0722638&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatograph; Electron

The Chemistry Department at Virginia Polytechnic Institute and State University will acquire a liquid chromatograph electrospray ionization mass spectrometer (LC-ESI-MS) with this award from the Major Research Instrumentation program. This will be used in a diverse body of research projects including studies of: bioactive natural products; derivatives of paclitaxel; radical ions and unimolecular rearrangements; dipeptide-borinic acids as malarial protease inhibitors; synthetic methods and medicinal chemistry; conformationally constrained peptide mimics; carbonaceous nanomaterials; dendritic sulfates as topical anti-infectives; molecular magnets; light-harvesting supramolecular assemblies; pseudorotaxanes, rotaxanes and polyrotaxanes; macromolecular synthesis; highly fluorinated Diels-Alder polyphenylenes.Mass spectroscopy is a basic tool used by physical and biological scientists to identify and characterize materials and chemical species by accurate measurement of their mass and fragmentation patterns as they are vaporized and ionized in the instrument. Liquid chromatography is an isolation technique that separates a complex mixture into individual components before introduced to the mass spectrometer. These are important tools to be introduced into the training of young scientists. This instrument will be used hands-on by undergraduate and graduate students, and post docs in their research.

弗吉尼亚理工学院暨州立大学化学系将获得重大研究仪器计划授予的液相色谱电喷雾电离质谱仪 (LC-ESI-MS)。 这将用于多种研究项目，包括以下研究：生物活性天然产物；紫杉醇衍生物；自由基离子和单分子重排；二肽硼酸作为疟疾蛋白酶抑制剂；合成方法和药物化学；构象限制的肽模拟物；碳质纳米材料；树枝状硫酸盐作为局部抗感染剂；分子磁体；光捕获超分子组装体；拟轮烷、轮烷和聚轮烷；高分子合成；质谱是物理和生物科学家使用的一种基本工具，通过精确测量材料和化学物质在仪器中汽化和电离时的质量和碎片模式来识别和表征材料和化学物质。 液相色谱是一种分离技术，可在引入质谱仪之前将复杂的混合物分离成单独的组分。 这些是年轻科学家培训中引入的重要工具。 该工具将供本科生、研究生以及博士后在研究中实际使用。