MRI: Acquisition of a Liquid Chromatograph Electron Spray Ionization Mass Spectrometer

弗吉尼亚理工学院和州立大学的化学系将从主要研究仪器计划获得一台液体色谱仪电喷雾电离质谱仪(LC-ESI-MS)。这将被用于各种各样的研究项目，包括研究：生物活性天然产物；紫杉醇的衍生物；自由基离子和单分子重排；用作疟疾蛋白酶抑制剂的二肽-硼酸；合成方法和药物化学；构象受限多肽模拟物；碳质纳米材料；树枝状硫酸盐作为局部抗感染药物；分子磁体；捕光超分子组件；拟黄烷、轮烷和聚轮烷；大分子合成；高氟Diels-Alder多苯。质谱学是物理和生物科学家使用的基本工具，通过准确测量材料和化学物种在仪器中蒸发和电离的质量和碎片模式来鉴定和表征它们。液相色谱是一种分离技术，它将复杂的混合物分离成单独的组分，然后引入质谱仪。这些都是可以引入到青年科学家培训中的重要工具。本科生、研究生和博士后将在他们的研究中使用该仪器。

The Chemistry Department at Virginia Polytechnic Institute and State University will acquire a liquid chromatograph electrospray ionization mass spectrometer (LC-ESI-MS) with this award from the Major Research Instrumentation program. This will be used in a diverse body of research projects including studies of: bioactive natural products; derivatives of paclitaxel; radical ions and unimolecular rearrangements; dipeptide-borinic acids as malarial protease inhibitors; synthetic methods and medicinal chemistry; conformationally constrained peptide mimics; carbonaceous nanomaterials; dendritic sulfates as topical anti-infectives; molecular magnets; light-harvesting supramolecular assemblies; pseudorotaxanes, rotaxanes and polyrotaxanes; macromolecular synthesis; highly fluorinated Diels-Alder polyphenylenes.Mass spectroscopy is a basic tool used by physical and biological scientists to identify and characterize materials and chemical species by accurate measurement of their mass and fragmentation patterns as they are vaporized and ionized in the instrument. Liquid chromatography is an isolation technique that separates a complex mixture into individual components before introduced to the mass spectrometer. These are important tools to be introduced into the training of young scientists. This instrument will be used hands-on by undergraduate and graduate students, and post docs in their research.