Arabidopsis 2010: Collaborative Research: Evolution of gene position and function in Arabidopsis using outgroup genomes
拟南芥 2010:合作研究:利用外群基因组研究拟南芥基因位置和功能的进化
基本信息
- 批准号:0821096
- 负责人:
- 金额:$ 61.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-02-15 至 2014-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Abstract Over time, the position of a gene in its genome often changes, but the functional consequences of such gene movements are largely unknown. To help fill this gap, these three investigators are not only exploiting the wealth of research tools and resources available for the model plant Arabidopsis, along with the genome sequences for papaya, grape, and poplar, they are also creating new ones. Focusing on Arabidopsis's 26,500 non-transposon, non-tandem genes, and using a new top-down, multi-alignment algorithm to infer gene order in the last common ancestor of Arabidopsis and papaya, grape, and poplar, the investigators have found evidence for an ancient hexaploidy shared by all dicots and perhaps all plants. Additional preliminary data show that about 40% of Arabidopsis genes are no longer ancestral, either because they (1) have diverged rapidly; (2) exhibit a high birth-and-death behavior in the phylogenetic tree; (3) are positioned in rearrangement-prone regions of the chromosome; or (4) have transposed to new locations in the genome. Interestingly, a "flanking gene test" has shown that certain gene families contain genes that are almost always newly transposed. The investigators also show that conserved noncoding sequences sometimes subfunctionalize among homeologs. Over 4,000 deeply conserved noncoding sequences (CNSs) are shared between papaya and Arabidopsis. These regulatory sites will be sorted to gene, made into a database, and evaluated for subfunctionalization at the level of sequence, gene expression, and fitness (reproductive output) through the use of knockout mutations and phenotypic analyses. In addition, using microarray data normalized by The Arabidopsis Information Resource (TAIR), the investigators will test, in silico, hypotheses concerning issues such as the relationship between genes' positions and their coregulation. Broader Impacts of Project. This project provides exciting training opportunities at both pre- and postgraduate levels. The investigators will continue their long-established partnerships with Chevron on the SEED project, and with Berkeley High School on improving biology training for promising, underserved minority high school students. The Freeling laboratory provides these students with paid summer research experiences tailored to the needs of the students and their families. The University of Georgia ranks sixth in the US in percentage of minorities, and research there is closely tied to strong outreach programs. This project will contribute to the development and implementation of research-based educational materials to improve comprehension and mastery of scientific concepts by middle and high school students through training of one teacher per year in the GIFT (Georgia Internships for Teachers) program. Together with GIFT, the investigators seek to nucleate a "teachers-teach-teachers" program that uses metaphorical examples and dialogue to portray key scientific concepts without becoming ensnarled in the debate on creationism, an issue prominent in many areas, including Georgia and South Carolina. In addition, exchanges between the three institutions will enhance the scientific and cultural experiences of these investigators students and add further to the bonds formed by research collaboration. The investigators on this project will communicate with the public and provide data and applications for download at their NSF 2010 project-specific website, http://www.plantgenome.uga.edu/outgroup.html .
随着时间的推移,基因在其基因组中的位置经常发生变化,但这种基因运动的功能后果在很大程度上是未知的。为了填补这一空白,这三位研究人员不仅利用模式植物拟南芥的丰富研究工具和资源,沿着木瓜、葡萄和白杨的基因组序列,他们还在创造新的研究工具和资源。研究人员专注于拟南芥的26,500个非转座子,非串联基因,并使用一种新的自上而下,多重比对算法来推断拟南芥和木瓜,葡萄和白杨的最后共同祖先的基因顺序,研究人员发现了所有双子叶植物,也许所有植物共享的古老六倍体的证据。另外的初步数据表明,大约40%的拟南芥基因不再是祖先,因为它们(1)已经迅速分化;(2)在系统发育树中表现出高的出生和死亡行为;(3)位于染色体的重复倾向区域;或(4)已经转座到基因组中的新位置。有趣的是,一项“侧翼基因测试”表明,某些基因家族包含的基因几乎总是新转座的。研究人员还表明,保守的非编码序列有时在同源物中亚功能化。木瓜和拟南芥之间共有超过4,000个高度保守的非编码序列(CNSs)。这些调控位点将按基因分类,制成数据库,并通过使用敲除突变和表型分析在序列、基因表达和适应性(生殖输出)水平上评价亚功能化。此外,使用拟南芥信息资源(TAIR)标准化的微阵列数据,研究人员将通过计算机测试有关基因位置及其协同调节之间关系等问题的假设。项目的更广泛影响。这个项目提供了令人兴奋的培训机会,在两个前和研究生水平。调查人员将继续与雪佛龙在SEED项目上建立长期合作伙伴关系,并与伯克利高中合作,改善对有前途、服务不足的少数族裔高中生的生物培训。Freeling实验室为这些学生提供针对学生及其家庭需求的带薪暑期研究体验。格鲁吉亚大学的少数族裔比例在美国排名第六,那里的研究与强大的外展计划密切相关。该项目将通过每年在GIFT(格鲁吉亚教师实习)方案中培训一名教师,促进编写和实施以研究为基础的教材,以提高初中和高中学生对科学概念的理解和掌握。与GIFT一起,调查人员寻求形成一个“教师-教学-教师”计划,该计划使用隐喻的例子和对话来描绘关键的科学概念,而不会陷入关于神创论的辩论,这是一个在许多地区都很突出的问题,包括格鲁吉亚和南卡罗来纳州。此外,三个机构之间的交流将加强这些研究生的科学和文化经验,并进一步加强研究合作所形成的纽带。该项目的研究人员将与公众沟通,并在其NSF 2010项目专用网站http://www.plantgenome.uga.edu/outgroup.html上提供数据和应用程序供下载。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Andrew Paterson其他文献
Sa1816 – Elevated Fecal Calprotectin in Healthy First Degree Relatives of Patients with Crohn's Disease is Associated with Future Diagnosis of Crohn's Disease
- DOI:
10.1016/s0016-5085(19)37883-7 - 发表时间:
2019-05-01 - 期刊:
- 影响因子:
- 作者:
Sun-Ho Lee;Namita Power;Williams Turpin;Larbi Bedrani;Juan Antonio Raygoza Garay;Michelle I. Smith;Karen Madsen;Dan Turner;John K. Marshall;Ernest G. Seidman;Charles N. Bernstein;Brian G. Feagan;Paul Moayyedi;A. Hillary Steinhart;Mark S. Silverberg;Anne M. Griffiths;Osvaldo Espin-Garcia;Wei Xu;Andrew Paterson;Kenneth Croitoru - 通讯作者:
Kenneth Croitoru
Quantified MRI measurements show the significance of indirect decompression in the lumbar spine
- DOI:
10.1007/s00586-025-08704-4 - 发表时间:
2025-02-05 - 期刊:
- 影响因子:2.700
- 作者:
Casey A. Slattery;Solomon Oloyede;Kylan Larsen;Andrew Paterson;Urvij Modhia;Umesh Metkar - 通讯作者:
Umesh Metkar
Su1980 THE GEM PROJECT: IMPAIRED GUT BARRIER FUNCTION IS ASSOCIATED WITH FUTURE DEVELOPMENT OF CROHN'S DISEASE EVEN IN THE PRESENCE OR ABSCENCE OF PRECLINICAL INFLAMMATION IN ASYMPTOMATIC FIRST-DEGREE RELATIVES OF CROHN'S PATIENTS
- DOI:
10.1016/s0016-5085(20)32506-3 - 发表时间:
2020-05-01 - 期刊:
- 影响因子:
- 作者:
Sun-Ho Lee;Williams Turpin;Juan Antonio Raygoza Garay;Karen Madsen;Jon Meddings;Larbi Bedrani;Namita Power;Wei Xu;Michelle I. Smith;Anne M. Griffiths;Paul Moayyedi;Dan Turner;Ernest G. Seidman;A. Hillary Steinhart;John K. Marshall;Kevan Jacobson;David R. Mack;Hien Q. Huynh;Charles N. Bernstein;Andrew Paterson - 通讯作者:
Andrew Paterson
96 – Increased Intestinal Permeability is a Predictor of Crohn's Disease Development in a Large Cohort of Asymptomatic First Degree Relatives
- DOI:
10.1016/s0016-5085(19)36830-1 - 发表时间:
2019-05-01 - 期刊:
- 影响因子:
- 作者:
Williams Turpin;Larbi Bedrani;Karen Madsen;Jon Meddings;Michelle I. Smith;Anne M. Griffiths;Mark S. Silverberg;Paul Moayyedi;Wei Xu;Osvaldo Espin-Garcia;John K. Marshall;Ernest G. Seidman;Mark Ropeleski;Brian G. Feagan;David R. Mack;Kevan Jacobson;Dan Turner;Thomas D. Walters;Andrew Paterson;Kenneth Croitoru - 通讯作者:
Kenneth Croitoru
Change Management in TVET Colleges: Lessons Learnt from the Field of Practice
TVET 学院的变革管理:实践领域的经验教训
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Andre Kraak;Andrew Paterson - 通讯作者:
Andrew Paterson
Andrew Paterson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Andrew Paterson', 18)}}的其他基金
GCR: Accelerating Progress Toward Intrinsic Genetic Solutions to Sustainable Agricultural Intensification
GCR:加速实现可持续农业集约化的内在遗传解决方案
- 批准号:
1934481 - 财政年份:2019
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
PFI-RP: Accelerating the improvement of US cotton fiber quality
PFI-RP:加速美国棉纤维品质提升
- 批准号:
1919078 - 财政年份:2019
- 资助金额:
$ 61.91万 - 项目类别:
Standard Grant
AIR: Accelerating deployment of novel alleles in cotton
AIR:加速棉花中新型等位基因的部署
- 批准号:
1127755 - 财政年份:2011
- 资助金额:
$ 61.91万 - 项目类别:
Standard Grant
PFI: Scaling a New Adaptive Peak for Cotton
PFI:攀登棉花适应新高峰
- 批准号:
0917856 - 财政年份:2009
- 资助金额:
$ 61.91万 - 项目类别:
Standard Grant
Unraveling the Course of Angiosperm Chromosome Evolution
揭示被子植物染色体进化的过程
- 批准号:
0450260 - 财政年份:2005
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
FIBR Planning: Why are so many Plants Polyploid?
FIBR 规划:为什么这么多植物是多倍体?
- 批准号:
0402372 - 财政年份:2004
- 资助金额:
$ 61.91万 - 项目类别:
Standard Grant
BAC Resources for Comparative Biology in Selected Angiosperms
BAC 选定被子植物比较生物学资源
- 批准号:
0208311 - 财政年份:2002
- 资助金额:
$ 61.91万 - 项目类别:
Standard Grant
Grass Genome Biodiversity: Application of Genomic Tools from Sorghum and Related Grasses to Identify and Analyze Variation in Structure and Function of C4 Grass Genomes
草基因组生物多样性:应用高粱和相关草的基因组工具来识别和分析 C4 草基因组结构和功能的变异
- 批准号:
0115903 - 财政年份:2001
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
相似国自然基金
云南地域建筑观念史比较研究1950-2010
- 批准号:
- 批准年份:2019
- 资助金额:39 万元
- 项目类别:地区科学基金项目
2010年青海玉树地震(Ms=7.1)产生超剪切破裂的动力学机制研究
- 批准号:41874060
- 批准年份:2018
- 资助金额:63.0 万元
- 项目类别:面上项目
观念、文本、阐释:当代西南现代建筑“地方性”思想话语演变研究(1950s-2010s)
- 批准号:51868027
- 批准年份:2018
- 资助金额:40.0 万元
- 项目类别:地区科学基金项目
铜绿假单胞菌PA2010调控PQS群体感应系统的机制及其功能研究
- 批准号:31700064
- 批准年份:2017
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
超新星 SN2010jl 对尘埃形成的启示
- 批准号:11763007
- 批准年份:2017
- 资助金额:42.0 万元
- 项目类别:地区科学基金项目
VLBI2010技术的时间比对应用研究
- 批准号:11603001
- 批准年份:2016
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
独创的MyD88抑制剂靶向防治GVHD的新策略及机理
- 批准号:81471588
- 批准年份:2014
- 资助金额:71.0 万元
- 项目类别:面上项目
2010年玉树Ms7.1级地震为玉树断裂带上一次非特征滑动事件的确定
- 批准号:41472200
- 批准年份:2014
- 资助金额:92.0 万元
- 项目类别:面上项目
基于TEOS-10构建中国海海水绝对盐度计算模型的研究
- 批准号:41406024
- 批准年份:2014
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
VLBI2010技术在解算EOP参数和COMPASS卫星精密定轨中的应用研究
- 批准号:41374042
- 批准年份:2013
- 资助金额:70.0 万元
- 项目类别:面上项目
相似海外基金
Collaborative Research: Arabidopsis 2010: Dissecting Cortical Actin Function during Arabidopsis-Pseudomonas Interactions
合作研究:拟南芥 2010:剖析拟南芥-假单胞菌相互作用期间的皮质肌动蛋白功能
- 批准号:
1021463 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Collaborative Research: Arabidopsis 2010: Deciphering mRNP Networks
合作研究:拟南芥 2010:破译 mRNP 网络
- 批准号:
1021969 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Collaborative Research (Arabidopsis 2010): Ecological Genomics of Adaptation to the Environment
合作研究(拟南芥2010):适应环境的生态基因组学
- 批准号:
1022236 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Collaborative Research: Arabidopsis 2010: Dissecting Cortical Actin Function during Arabidopsis-Pseudomonas Interactions
合作研究:拟南芥 2010:剖析拟南芥-假单胞菌相互作用期间的皮质肌动蛋白功能
- 批准号:
1021185 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Collaborative Research: Arabidopsis 2010: Ecological genomics of adaptation to climate
合作研究:拟南芥2010:适应气候的生态基因组学
- 批准号:
1022196 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Collaborative Research: Arabidopsis 2010: Dissecting Cortical Actin Function during Arabidopsis-Pseudomonas Interactions
合作研究:拟南芥 2010:剖析拟南芥-假单胞菌相互作用期间的皮质肌动蛋白功能
- 批准号:
1021044 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Collaborative Research (Arabidopsis 2010): Ecological Genomics of Adaptation to the Environment
合作研究(拟南芥2010):适应环境的生态基因组学
- 批准号:
1022202 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Collaborative Research: Arabidopsis 2010: Deciphering mRNP Networks
合作研究:拟南芥 2010:破译 mRNP 网络
- 批准号:
1022435 - 财政年份:2010
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Arabidopsis 2010 Project Collaborative Research: Modeling Biological Networks in Arabidopsis through Integration of Genomic, Proteomic, and Metabolomic Data
拟南芥 2010 项目合作研究:通过整合基因组、蛋白质组和代谢组数据模拟拟南芥生物网络
- 批准号:
0820674 - 财政年份:2009
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant
Arabidopsis 2010 Project Collaborative Research: Modeling Biological Networks in Arabidopsis through Integration of Genomic, Proteomic, and Metabolomic Data
拟南芥 2010 项目合作研究:通过整合基因组、蛋白质组和代谢组数据模拟拟南芥生物网络
- 批准号:
0820717 - 财政年份:2009
- 资助金额:
$ 61.91万 - 项目类别:
Continuing Grant