Adapting to a Duplicated Genome

适应重复的基因组

基本信息

项目摘要

Intellectual Merit.Higher organisms occasionally form aberrant individuals with their entire genetic blueprint doubled relative to that of their parents. While the vast majority of these individuals quickly go extinct, in exceedingly rare cases such "genome duplications" give rise to new lineages that appear to realize numerous advantages resulting from having "spare" copies of each gene. Across hundreds of millions of years of evolution, these rare "success stories" collectively are one of the most important mechanisms by which new genes and new functions evolve. Flowering plants (angiosperms) are more tolerant of genome duplication than most taxa - virtually all have experienced genome duplication at least once and sometimes 3-4 times in the past 150-200 million years, and many neo-polyploids formed in the past 1-2 million years are known including many major crops. With the sequences of a growing number of angiosperm genomes now available, the investigators have identified a population of genes that are distinctive in having (a) higher-than average rates of loss for one but not both member(s) of duplicate pairs, (b) convergent fates across multiple independent duplication events within and/or among lineages, and (c) a higher-than-random degree of correlated gene expression. Herein, the investigators will begin empirical tests of fitness effects associated with both the general population of these "duplication-resistant" genes and specific members, seeking genetic probes into pathways and functions contributing to adaptation of a genome to the duplicated state. Broader Impacts. The experimental facility of Arabidopsis will expedite analysis of some of the most important evolutionary forces shaping eukaryotic genomes, and in particular underlying the biodiversity that enables angiosperms to provide many ecosystem services including most of the worlds food, feed, and fiber. Better understanding of adaptation by a lineage to genome duplication is not only of fundamental interest but may also have practical applications, either directly by improving productivity of polyploid crops, or indirectly by mitigating obstacles to wider use of naturally-occurring germplasm resources in crop improvement. This research is closely tied to the education of students and the public, providing training opportunities at both pre- and postgraduate levels, and contributing to development and implementation of research-based educational materials to improve achievement, comprehension and mastery of scientific concepts by middle and high school students, also building the nucleus for a "teachers teach teachers" program.This project is co-funded by the Arabidopsis 2010 Project.
智力优点:高等生物偶尔会形成异常个体,其整个遗传蓝图相对于其父母加倍。 虽然这些个体中的绝大多数很快就灭绝了,但在极少数情况下,这种“基因组复制”会产生新的谱系,这些谱系似乎意识到每个基因的“备用”拷贝带来的许多优势。 在数亿年的进化过程中,这些罕见的“成功故事”是新基因和新功能进化的最重要机制之一。 有花植物(被子植物)比大多数分类群更能耐受基因组复制-在过去的1.5 - 2亿年中,几乎所有的植物都经历过至少一次基因组复制,有时3-4次,并且已知在过去的1-2百万年中形成的许多新多倍体,包括许多主要作物。 随着越来越多的被子植物基因组序列的可用性,研究人员已经确定了一个基因群体,其独特之处在于:(a)重复对中一个而不是两个成员的丢失率高于平均值,(B)在谱系内和/或谱系之间的多个独立重复事件中的趋同命运,以及(c)相关基因表达的随机程度高于随机程度。在此,研究人员将开始与这些“抗复制”基因的一般群体和特定成员相关的适应性效应的经验测试,寻找有助于基因组适应复制状态的途径和功能的遗传探针。更广泛的影响。拟南芥的实验设施将加快对一些塑造真核生物基因组的最重要的进化力量的分析,特别是使被子植物能够提供许多生态系统服务的生物多样性,包括世界上大多数的食物,饲料和纤维。更好地理解谱系对基因组复制的适应不仅具有根本意义,而且还可能具有实际应用,直接通过提高多倍体作物的生产力,或间接通过减轻在作物改良中更广泛使用天然存在的种质资源的障碍。这项研究与学生和公众的教育密切相关,提供预科和研究生两级的培训机会,并有助于制定和实施基于研究的教育材料,以提高初中和高中学生对科学概念的理解和掌握,同时也是“教师教教师”项目的核心。该项目由拟南芥2010项目共同资助。

项目成果

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Andrew Paterson其他文献

Sa1816 – Elevated Fecal Calprotectin in Healthy First Degree Relatives of Patients with Crohn's Disease is Associated with Future Diagnosis of Crohn's Disease
  • DOI:
    10.1016/s0016-5085(19)37883-7
  • 发表时间:
    2019-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sun-Ho Lee;Namita Power;Williams Turpin;Larbi Bedrani;Juan Antonio Raygoza Garay;Michelle I. Smith;Karen Madsen;Dan Turner;John K. Marshall;Ernest G. Seidman;Charles N. Bernstein;Brian G. Feagan;Paul Moayyedi;A. Hillary Steinhart;Mark S. Silverberg;Anne M. Griffiths;Osvaldo Espin-Garcia;Wei Xu;Andrew Paterson;Kenneth Croitoru
  • 通讯作者:
    Kenneth Croitoru
Quantified MRI measurements show the significance of indirect decompression in the lumbar spine
  • DOI:
    10.1007/s00586-025-08704-4
  • 发表时间:
    2025-02-05
  • 期刊:
  • 影响因子:
    2.700
  • 作者:
    Casey A. Slattery;Solomon Oloyede;Kylan Larsen;Andrew Paterson;Urvij Modhia;Umesh Metkar
  • 通讯作者:
    Umesh Metkar
Su1980 THE GEM PROJECT: IMPAIRED GUT BARRIER FUNCTION IS ASSOCIATED WITH FUTURE DEVELOPMENT OF CROHN'S DISEASE EVEN IN THE PRESENCE OR ABSCENCE OF PRECLINICAL INFLAMMATION IN ASYMPTOMATIC FIRST-DEGREE RELATIVES OF CROHN'S PATIENTS
  • DOI:
    10.1016/s0016-5085(20)32506-3
  • 发表时间:
    2020-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sun-Ho Lee;Williams Turpin;Juan Antonio Raygoza Garay;Karen Madsen;Jon Meddings;Larbi Bedrani;Namita Power;Wei Xu;Michelle I. Smith;Anne M. Griffiths;Paul Moayyedi;Dan Turner;Ernest G. Seidman;A. Hillary Steinhart;John K. Marshall;Kevan Jacobson;David R. Mack;Hien Q. Huynh;Charles N. Bernstein;Andrew Paterson
  • 通讯作者:
    Andrew Paterson
96 – Increased Intestinal Permeability is a Predictor of Crohn's Disease Development in a Large Cohort of Asymptomatic First Degree Relatives
  • DOI:
    10.1016/s0016-5085(19)36830-1
  • 发表时间:
    2019-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Williams Turpin;Larbi Bedrani;Karen Madsen;Jon Meddings;Michelle I. Smith;Anne M. Griffiths;Mark S. Silverberg;Paul Moayyedi;Wei Xu;Osvaldo Espin-Garcia;John K. Marshall;Ernest G. Seidman;Mark Ropeleski;Brian G. Feagan;David R. Mack;Kevan Jacobson;Dan Turner;Thomas D. Walters;Andrew Paterson;Kenneth Croitoru
  • 通讯作者:
    Kenneth Croitoru
Change Management in TVET Colleges: Lessons Learnt from the Field of Practice
TVET 学院的变革管理:实践领域的经验教训
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Andre Kraak;Andrew Paterson
  • 通讯作者:
    Andrew Paterson

Andrew Paterson的其他文献

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{{ truncateString('Andrew Paterson', 18)}}的其他基金

GCR: Accelerating Progress Toward Intrinsic Genetic Solutions to Sustainable Agricultural Intensification
GCR:加速实现可持续农业集约化的内在遗传解决方案
  • 批准号:
    1934481
  • 财政年份:
    2019
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Continuing Grant
PFI-RP: Accelerating the improvement of US cotton fiber quality
PFI-RP:加速美国棉纤维品质提升
  • 批准号:
    1919078
  • 财政年份:
    2019
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Standard Grant
AIR: Accelerating deployment of novel alleles in cotton
AIR:加速棉花中新型等位基因的部署
  • 批准号:
    1127755
  • 财政年份:
    2011
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Standard Grant
A Plant Genome Duplication Database
植物基因组复制数据库
  • 批准号:
    0849896
  • 财政年份:
    2009
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Standard Grant
PFI: Scaling a New Adaptive Peak for Cotton
PFI:攀登棉花适应新高峰
  • 批准号:
    0917856
  • 财政年份:
    2009
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Standard Grant
Arabidopsis 2010: Collaborative Research: Evolution of gene position and function in Arabidopsis using outgroup genomes
拟南芥 2010:合作研究:利用外群基因组研究拟南芥基因位置和功能的进化
  • 批准号:
    0821096
  • 财政年份:
    2009
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Standard Grant
Unraveling the Course of Angiosperm Chromosome Evolution
揭示被子植物染色体进化的过程
  • 批准号:
    0450260
  • 财政年份:
    2005
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Continuing Grant
FIBR Planning: Why are so many Plants Polyploid?
FIBR 规划:为什么这么多植物是多倍体?
  • 批准号:
    0402372
  • 财政年份:
    2004
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Standard Grant
BAC Resources for Comparative Biology in Selected Angiosperms
BAC 选定被子植物比较生物学资源
  • 批准号:
    0208311
  • 财政年份:
    2002
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Standard Grant
Grass Genome Biodiversity: Application of Genomic Tools from Sorghum and Related Grasses to Identify and Analyze Variation in Structure and Function of C4 Grass Genomes
草基因组生物多样性:应用高粱和相关草的基因组工具来识别和分析 C4 草基因组结构和功能的变异
  • 批准号:
    0115903
  • 财政年份:
    2001
  • 资助金额:
    $ 73.53万
  • 项目类别:
    Continuing Grant

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A Bioinformatics Framework to Understand the Fate of Duplicated Genes in Evolution
了解进化中重复基因命运的生物信息学框架
  • 批准号:
    578495-2022
  • 财政年份:
    2022
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    $ 73.53万
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Alternative Splicing of Duplicated Genes in Polyploid Brassica napus
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CAREER: De novo assembly of duplicated sequences in vertebrate genomes
职业:脊椎动物基因组中重复序列的从头组装
  • 批准号:
    2046753
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    2021
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Genetic and functional assessment of human-specific duplicated genes
人类特异性重复基因的遗传和功能评估
  • 批准号:
    10156595
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    2021
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Alternative Splicing of Duplicated Genes in Polyploid Brassica napus
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    RGPIN-2021-03148
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Frontier Bioscience - Do duplicated genes drive morphological diversity?
Frontier Bioscience - 重复的基因会驱动形态多样性吗?
  • 批准号:
    2672567
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    2021
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    $ 73.53万
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Randomized Cardiovascular Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques of Epidemiology (RCT DUPLICATE)
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    10606588
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Randomized Cardiovascular Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques of Epidemiology (RCT DUPLICATE)
使用前瞻性纵向保险索赔重复的随机心血管试验:应用流行病学技术(RCT DUPLICATE)
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    9898456
  • 财政年份:
    2019
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Randomized Cardiovascular Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques of Epidemiology (RCT DUPLICATE)
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  • 批准号:
    10392863
  • 财政年份:
    2019
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    $ 73.53万
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Principle of chronic centrosome aberrations in whole-genome duplicated cells and its contribution to cellular heterogeneity
全基因组复制细胞慢性中心体畸变的原理及其对细胞异质性的贡献
  • 批准号:
    19H03219
  • 财政年份:
    2019
  • 资助金额:
    $ 73.53万
  • 项目类别:
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