MRI: Acquisition of a Liquid Chromatograph-ion Trap Mass Spectrometer for Undergraduate Research and Research Training

获得重大研究仪器(MRI)计划的这一奖项后，哈维·马德学院化学系将获得一台液体色谱仪-离子陷阱质谱仪。它将用于不同的研究领域，包括：1)天然产物化学，特别是软珊瑚属Alcyonium的化学分类，以及加州内生真菌的化学探索；2)合成天然产物化学，即合成二元酸的仿生环化反应；3)有机金属化学，特别是不对称氢胺化反应的催化剂设计；4)有机化学，涉及单线态氧反应的立体控制；5)液晶的物理化学，描述不对称2，7-二酰基氟液晶的热力学行为；6)物理无机化学和材料科学，侧重于金属卟啉二聚体中电子耦合的实验研究，以及锌卟啉在纳米氧化锌上的染料敏化太阳能电池中的耦合和电子注入。质谱学(MS)是化学家和生化学家通过测量样品中分子组成的质量来鉴定样品的化学成分和纯度的分析技术。层析是一种分离技术，它先于质谱分析。它将混合物分离成几种化学成分，然后由质谱仪进行分析和鉴定。这一现代化的工具将促进本科生的研究教育和培训。除了哈维穆德学院和克莱蒙特学院联合科学系的研究项目外，所要求的仪器还将服务于该地区的一个本科生学院联盟，为包括天然产品和生物化学研究的项目提供急需的支持。

With this award from the Major Research Instrumentation (MRI) program, the Department of Chemistry at Harvey Mudd College will acquire a liquid chromatograph-ion trap mass spectrometer. It will be used in various research areas including, 1) natural product chemistry, specifically the chemotaxonomy of the soft coral genus Alcyonium, as well as chemical explorations of California endophytic fungi; 2) synthetic natural product chemistry, namely biomimetic cyclizations in the synthesis of endiandric acids; 3) organometallic chemistry, specifically catalyst design for asymmetric hydroamination; 4) organic chemistry, concerning stereocontrol in reactions of singlet oxygen; 5) the physical chemistry of liquid crystals, describing the thermodynamic behavior of asymmetric 2,7-diacyl fluorine liquid crystals; and 6) physical inorganic chemistry and materials science, focusing on experimental investigation of electronic coupling in metalloporphyrin dimers, as well as coupling and electron injection in dye-sensitized solar cells using zinc porphyrins on nanostructured zinc oxide.Mass spectrometry (MS) is an analytical technique used by chemists and biochemists to identify the chemical composition of a sample and its purity by measuring the mass of the molecular constituents in the sample. Chromatography is an isolation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed and identified by the mass spectrometer. This modern instrumentation will improve the education and training of undergraduate students in research. In addition to research projects at Harvey Mudd College and the Joint Sciences Department of the Claremont Colleges, the requested instrument will serve a consortium of undergraduate colleges in the area, providing much needed support to projects encompassing the study of natural products and biochemistry.