MRI: Acquisition of a Liquid Chromatography-Tandem Mass Spectrometry Instrument for Research and Teaching in the Sciences at Union College

MRI：购买液相色谱-串联质谱仪用于联合学院的科学研究和教学

• 批准号: 0922883
• 负责人: Laura MacManus-Spencer
• 金额: $ 26万
• 依托单位: Union College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922883&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatography; Tandem

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, the Department of Chemistry at Union College will acquire a Liquid Chromatography-Triple Quadrupole Mass Spectrometry instrument (LC-MS/MS) to enable sophisticated analysis of a variety of nonvolatile organic chemicals and biomolecules, which will advance multiple areas of current research, primarily in the Departments of Chemistry and Biology, as well as in the Biochemistry and Environmental Studies programs. A variety of research projects will be pursued including: 1) studies of the environmental fate, transport, and bioaccumulation of ultraviolet filter chemicals, perfluorochemicals, and other emerging environmental contaminants; 2) molecular recognition investigations of biological macromolecules; 3) the identification of isolated natural products; 4) the structural identification of cell wall polysaccharides to study the relationship between net photosynthesis and polyuronic acid production in moss species; and 5) identification of potentially novel antifungal compounds produced by bacteria.Mass spectrometry (MS) is an analytical technique used to identify the chemical composition of a sample and to determine its purity by measuring the mass of the molecular constituents in the sample. Liquid chromatography is a separation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed and identified by the mass spectrometer. It is one of the fastest growing and most widely used analytical instrumentation techniques. Because of this, it is important for undergraduate students to be trained in the technique. In addition to enhancing research projects, the acquisition of an LC-MS/MS will transform several undergraduate laboratories, as it will be incorporated into Organic Chemistry, Quantitative Analysis, Chemical Instrumentation, Forensic Chemistry, and Biochemistry laboratories

该奖项是根据2009年美国复苏和再投资法案资助的（公法111-5）。通过重大研究仪器（MRI）计划的这一奖项，联合学院化学系将获得液相色谱-三重四极杆质谱仪（LC-MS/MS）能够对各种非挥发性有机化学品和生物分子进行复杂的分析，这将推动当前研究的多个领域，主要是在化学和生物学系，以及在生物化学和环境研究计划。 将开展各种研究项目，包括：1）紫外线过滤化学品、全氟化学品和其他新出现的环境污染物的环境归宿、运输和生物累积研究; 2）生物大分子的分子识别研究; 3）分离的天然产物的鉴定;（4）细胞壁多糖的结构鉴定，以研究藓类植物光合作用与多糖醛酸产生的关系; 5）鉴定由细菌产生的潜在新型抗真菌化合物质谱（MS）是一种分析技术，用于鉴定样品的化学组成，并通过测量样品中分子组分的质量来确定其纯度。 液相色谱是一种先于质谱分析的分离技术。 它将混合物分离成几种化学成分，然后由质谱仪进行分析和鉴定。 它是发展最快、使用最广泛的分析仪器技术之一。正因为如此，它是重要的本科生在技术培训。 除了加强研究项目外，LC-MS/MS的收购还将改变几个本科实验室，因为它将被纳入有机化学，定量分析，化学仪器，法医化学和生物化学实验室