EAGER: BISH: Biophotonics Technique for Detection of Lung Cancer

EAGER：BISH：用于检测肺癌的生物光子学技术

• 批准号: 0939778
• 负责人: Vadim Backman
• 金额: $ 30万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0939778&HistoricalAwards=false
• 关键词: EAGER; BISH; Biophotonics; Technique; Detection

0939778BackmanThe PI proposes a new paradigm where the presence of lung cancer is detected by analysis of readily accessible histologically normal-appearing buccal cells that are readily obtained by a check swab from the buccal mucosa. This idea is based on Dr. Backman's development of partial wave spectroscopic (PWS) microscopy, which quantifies statistical properties of nanoscale cell structure. Using PWS, he demonstrated that an increase in the disorder of cell nanoarchitecture is one of the earliest events in carcinogenesis, which precedes any known microscale alterations. Importantly, it is not restricted to tumor cells but also present outside of cancerous or precancerous lesions. In this project they propose to extend this concept to lung cancer: Namely, PWS detection of field effect changes in buccal cells that are associated with lung cancer.

背景PI提出了一种新的范例，其中肺癌的存在是通过分析容易获得的组织学上看起来正常的口腔细胞来检测的，这些细胞很容易通过检查拭子从口腔粘膜中获得。这个想法是基于Backman博士发展的部分波谱(PWS)显微镜，它量化了纳米级细胞结构的统计特性。利用PWS，他证明了细胞纳米结构紊乱的增加是致癌过程中最早的事件之一，发生在任何已知的微尺度变化之前。重要的是，它并不局限于肿瘤细胞，也存在于癌或癌前病变之外。在这个项目中，他们建议将这一概念扩展到肺癌：即PWS检测与肺癌相关的口腔细胞的场效应变化。