EAGER: BISH: Biophotonics Technique for Detection of Lung Cancer

[09:39778 . backman] PI提出了一种新的模式，通过分析易于接近的组织学上看起来正常的口腔细胞来检测肺癌的存在，这些细胞可以通过口腔黏膜的检查拭子轻松获得。这个想法是基于巴克曼博士对部分波光谱（PWS）显微镜的发展，该显微镜量化了纳米级细胞结构的统计特性。利用PWS，他证明了细胞纳米结构紊乱的增加是致癌发生的最早事件之一，它先于任何已知的微尺度改变。重要的是，它不仅局限于肿瘤细胞，也存在于癌前病变的外部。在这个项目中，他们提出将这一概念扩展到肺癌：即PWS检测与肺癌相关的颊细胞的场效应变化。

0939778BackmanThe PI proposes a new paradigm where the presence of lung cancer is detected by analysis of readily accessible histologically normal-appearing buccal cells that are readily obtained by a check swab from the buccal mucosa. This idea is based on Dr. Backman's development of partial wave spectroscopic (PWS) microscopy, which quantifies statistical properties of nanoscale cell structure. Using PWS, he demonstrated that an increase in the disorder of cell nanoarchitecture is one of the earliest events in carcinogenesis, which precedes any known microscale alterations. Importantly, it is not restricted to tumor cells but also present outside of cancerous or precancerous lesions. In this project they propose to extend this concept to lung cancer: Namely, PWS detection of field effect changes in buccal cells that are associated with lung cancer.