SGER: Biophotonics Techniques for Accurate Diagnosis of Pancreatic Cancer

SGER：准确诊断胰腺癌的生物光子学技术

• 批准号: 0620303
• 负责人: Vadim Backman
• 金额: $ 15.24万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0620303&HistoricalAwards=false
• 关键词: SGER; Biophotonics; Techniques; Accurate; Diagnosis

0620303BackmanThe following Specific Aims are proposed:Specific Aim 1: Apply partial wave spectroscopy (PWS) to improve the ability of cytology todiagnose PC. They will assess fixed cytological samples previously obtained either by ERCP or EUS that were positive and negative to develop prediction rules and, importantly, test it in samples including a subgroup who were cytologically negative but later were diagnosed with pancreatic cancer. The completion of this study will also show the feasibility of a multi-institutional clinical trial where cytology specimens can be reliably exchanged for PWS analysis.Specific Aim 2: Demonstrate the potential of PWS to correctly identify patients withconcurrent pancreatic cancer based on the analysis of fresh cytological specimens. From theperspective of future clinical applications, PWS can be potentially used on either fixed or fresh cytological samples. Thus, it is important to compare the diagnostic performance of PWS between these two types of cytological preparations (i.e., fixed vs. fresh cells) and determine which one provides the optimal diagnostic performance.

具体目标1：应用部分波谱技术（PWS）提高细胞学诊断PC的能力。他们将评估先前通过ERCP或EUS获得的阳性和阴性的固定细胞学样本，以制定预测规则，重要的是，在包括细胞学阴性但后来被诊断为胰腺癌的亚组的样本中进行测试。这项研究的完成也将显示一个多机构的临床试验的可行性，细胞学标本可以可靠地交换PWS analysis.Specific Aim 2：展示PWS的潜力，以正确识别患者并发胰腺癌的基础上分析新鲜细胞学标本。从未来临床应用的角度来看，PWS可以潜在地用于固定或新鲜的细胞学样本。因此，重要的是比较这两种类型的细胞学制备物之间PWS的诊断性能（即，固定细胞与新鲜细胞），并确定哪一个提供最佳诊断性能。