SGER: Biophotonics for Diagnosis of Pancreatic Cancer

胰腺癌（PC）是所有主要癌症中预后最差的，五年生存率低于5%。PC致死性的原因与其倾向于在晚期被诊断有关，因为疾病的潜在可治愈阶段通常在临床上是沉默的。生存率很大程度上取决于PC被诊断的阶段。然而，胰腺癌是潜伏的，因为胰腺癌的发展通常预示着不可切除，因此是不可治愈的疾病。胰腺癌筛查的主要障碍之一是胰腺的任何检查都可能导致严重的并发症（并发症发生率约为20%）。因此，找到一种对患者进行风险分层的预筛查方法对于设计筛查策略至关重要。该项目的重点是开发生物光子学方法（部分波光谱显微技术）来解决这个问题。

CBET-0733868 Backman Pancreatic cancer (PC) has the worst prognosis of any major cancer, with a five-year survival rate below 5%. The reasons for the lethality of PC relates to its tendency to bediagnosed at a late stage given that potentially curable stages of disease are oftenclinically silent. Survival rate dramatically depends on the stage at which PC isdiagnosed. However, pancreatic cancer is insidious in that the development of symptomsgenerally portend unresectable and hence uncurable disease. One of the major hurdlespreventing screening for PC is that essentially any interrogation of the pancreas may leadto serious complications (~20% complication rate). Thus, finding a pre-screening method inwhich patients are risk-stratified would be critical for designing screening strategies.This project focuses on development of a biophotonics approach (a partial wave spectroscopic microscopic technique), to address this problem.